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  1. Metastasis is the most frequent type of recurrence in gastrointestinal (GI) cancers, and there is an emerging potential for new diagnostic and therapeutic approaches, especially in the cases of metastatic GI c...

    Authors: Elmira Gheytanchi, Zahra Madjd, Leila Janani, Arezoo Rasti, Roya Ghods, Fatemeh Atyabi, Mohammad Hossein Asadi-Lari and Sadegh Babashah

    Citation: Systematic Reviews 2017 6:228

    Content type: Protocol

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  2. Acutely ill patients are a heterogeneous group, and some of these suffer from organ failure. As the prognosis of organ failure improves with early treatment, it is important to identify these patients as early...

    Authors: Peter Bank Pedersen, Asbjorn Hrobjartsson, Daniel Lykke Nielsen, Daniel Pilsgaard Henriksen, Mikkel Brabrand and Annmarie Touborg Lassen

    Citation: Systematic Reviews 2017 6:227

    Content type: Protocol

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  3. Despite advances in treatment, acute myocardial infarction (MI) is still associated with significant morbidity and mortality, especially in patients with extensive damage and scar formation. Based on some prom...

    Authors: Carly C. Barron, Manoj M. Lalu, Duncan J. Stewart, Dean Fergusson, Homer Yang, David Moher, Peter Liu, David Mazer, P. J. Devereaux and Lauralyn McIntyre

    Citation: Systematic Reviews 2017 6:226

    Content type: Protocol

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  4. Previous systematic reviews have examined preterm infants’ long-term neurodevelopment after neonatal intensive care unit (NICU) discharge, although none have explored the effectiveness of interventions on pret...

    Authors: Marilyn Aita, Robyn Stremler, Nancy Feeley, Andréane Lavallée and Gwenaëlle De Clifford-Faugère

    Citation: Systematic Reviews 2017 6:225

    Content type: Protocol

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  5. Psychosocial factors play an important role in chronic musculoskeletal pain disorders. Although psychosocial stress is likely to contribute to the development of chronic musculoskeletal pain, investigations ar...

    Authors: Valentina Buscemi, Wei-Ju Chang, Matthew B. Liston, James H. McAuley and Siobhan Schabrun

    Citation: Systematic Reviews 2017 6:224

    Content type: Protocol

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  6. The economic determinants of health have been widely recognised as crucial factors affecting health; however, to date, no comprehensive review has been undertaken to summarise these factors and the ways in whi...

    Authors: Yannish Naik, Peter Baker, Ian Walker, Taavi Tillmann, Kristin Bash, Darryl Quantz, Frances Hillier-Brown and Clare Bambra

    Citation: Systematic Reviews 2017 6:222

    Content type: Protocol

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    The Correction to this article has been published in Systematic Reviews 2019 8:233

  7. This systematic review is the first step in a study investigating the resilience methods and processes in families of children with juvenile idiopathic arthritis. In particular, this review will focus on chron...

    Authors: Sophia Saetes, Lisa Hynes, Brian E. McGuire and Line Caes

    Citation: Systematic Reviews 2017 6:221

    Content type: Protocol

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  8. Non-communicable diseases (NCDs) are the leading cause of death worldwide. Clinical practice guidelines (CPGs) constitute an important tool for the promotion of evidence-based health, which may improve healthc...

    Authors: Caroline de Godoi Rezende Costa Molino, Eliane Ribeiro, Nicolina Silvana Romano-Lieber, Airton Tetelbom Stein and Daniela Oliveira de Melo

    Citation: Systematic Reviews 2017 6:220

    Content type: Protocol

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  9. Stroke is a growing global epidemic limiting the ability of millions to function independently due to post-stroke deficits and complications. Although specialized stroke rehabilitation improves the recovery of...

    Authors: Michael Pugliese, Dylan Johnson, Dar Dowlatshahi and Tim Ramsay

    Citation: Systematic Reviews 2017 6:219

    Content type: Protocol

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  10. The Contextualized Health Research Synthesis Program (CHRSP), developed in 2007 by the Newfoundland and Labrador Centre for Applied Health Research, produces contextualized knowledge syntheses for health-syste...

    Authors: Stephen Bornstein, Rochelle Baker, Pablo Navarro, Sarah Mackey, David Speed and Melissa Sullivan

    Citation: Systematic Reviews 2017 6:218

    Content type: Methodology

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  11. For many vital signs, monitoring methods require contact with the patient and/or are invasive in nature. There is increasing interest in developing still and video image-guided monitoring methods that are non-...

    Authors: Mirae Harford, Jacqueline Catherall, Stephen Gerry, Duncan Young and Peter Watkinson

    Citation: Systematic Reviews 2017 6:217

    Content type: Protocol

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  12. Obesity and dental caries are global public health problems which can impact in childhood and throughout the life course. In simple terms, childhood dental caries and body weight are linked via the common risk...

    Authors: Susan J. Carson, Lamis Abuhaloob, Derek Richards, Mark P. Hector and Ruth Freeman

    Citation: Systematic Reviews 2017 6:216

    Content type: Protocol

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  13. Rapid and accurate diagnosis of tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Many established diagnostic methods suffer from low sensitivity or delay of timely re...

    Authors: Emmanuel O. Babafemi, Benny P. Cherian, Lee Banting, Graham A. Mills and Kandala Ngianga II

    Citation: Systematic Reviews 2017 6:215

    Content type: Research

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  14. People with long-term serious mental illness live with severe and debilitating symptoms that can negatively influence their health and quality of life, leading to outcomes such as premature mortality, morbidit...

    Authors: Helen Quirk, Helen Crank, Deborah Harrop, Emma Hock and Robert Copeland

    Citation: Systematic Reviews 2017 6:214

    Content type: Protocol

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  15. Information-seeking behaviour is necessary to improve knowledge on diabetes therapy and complications. Combined with other self-management skills and autonomous handling of the disease, it is essential for ach...

    Authors: Silke Kuske, Tim Schiereck, Sandra Grobosch, Andrea Paduch, Sigrid Droste, Sarah Halbach and Andrea Icks

    Citation: Systematic Reviews 2017 6:212

    Content type: Research

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    The Correction to this article has been published in Systematic Reviews 2017 6:241

  16. The incorporation of Behavioral Change Techniques (BCTs) in eHealth interventions for the management of non-communicable diseases (NCDs), such as type 2 diabetes mellitus (T2DM), might be a promising approach ...

    Authors: Mihiretu Kebede, Lara Christianson, Zohaib Khan, Thomas L. Heise and Claudia R. Pischke

    Citation: Systematic Reviews 2017 6:211

    Content type: Protocol

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  17. Authors’ response to comments letter to the editor from Nachman KE et al.

    Authors: Annette M. O’Connor, Brent W. Auvermann, Rungano S. Dzikamunhenga, Julie M. Glanville, Julian P. T. Higgins, Shelley P. Kirychuk, Jan M. Sargeant, Sarah C. Totton, Hannah Wood and Susanna G. Von Essen

    Citation: Systematic Reviews 2017 6:210

    Content type: Commentary

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  18. The receptionist is the focal point of the practice, undertaking an array of clinically orientated roles such as triaging patients for GP consultations or managing repeat prescribing. However, the full nature ...

    Authors: Michael Burrows, Nicola Gale, Sheila Greenfield and Ian Litchfield

    Citation: Systematic Reviews 2017 6:209

    Content type: Protocol

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  19. Social network analysis quantifies and visualizes relationships between and among individuals or organizations. Applications in the health sector remain underutilized. This systematic review seeks to analyze w...

    Authors: Kate Sabot, Deepthi Wickremasinghe, Karl Blanchet, Bilal Avan and Joanna Schellenberg

    Citation: Systematic Reviews 2017 6:208

    Content type: Research

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  20. Therapeutic exercises play a crucial role in the management of burn injuries. The broad objective of this review is to systematically evaluate the effectiveness, safety and applicability to low-income countrie...

    Authors: Tapfuma Mudawarima, Matthew Chiwaridzo, Jennifer Jelsma, Karen Grimmer and Faith Chengetayi Muchemwa

    Citation: Systematic Reviews 2017 6:207

    Content type: Protocol

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  21. Each year, about 500,000 people suffer a cardiac arrest (either out-of-hospital or in-hospital) in the USA. Although significant improvements in survival have occurred through the implementation of complex hig...

    Authors: Guillaume Geri, Joshua Gilgan, Carolyn Ziegler, Wanrudee Isaranuwatchai and Laurie J. Morrison

    Citation: Systematic Reviews 2017 6:205

    Content type: Protocol

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  22. Assessment of the quality of included studies is an essential component of any systematic review. A formal quality assessment is facilitated by using a structured tool. There are currently no guidelines availa...

    Authors: Penny Whiting, Robert Wolff, Susan Mallett, Iveta Simera and Jelena Savović

    Citation: Systematic Reviews 2017 6:204

    Content type: Methodology

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  23. While hospitalized in the NICU, preterm neonates undergo many painful procedures. This may be the same for full-term neonates when longer hospitalization is required. Untreated and repeated pain has short-term...

    Authors: Gwenaëlle De Clifford-Faugère, Andréane Lavallée and Marilyn Aita

    Citation: Systematic Reviews 2017 6:203

    Content type: Protocol

    Published on:

  24. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of high-flow oxygen via nasal cannulae (HFNC) compared to non-invasive ventilation (NIV) and/or standard oxygen in patient...

    Authors: Murdoch Leeies, Eric Flynn, Alexis F. Turgeon, Bojan Paunovic, Hal Loewen, Rasheda Rabbani, Ahmed M. Abou-Setta, Niall D. Ferguson and Ryan Zarychanski

    Citation: Systematic Reviews 2017 6:202

    Content type: Research

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  25. Hydrocephalus is a recognised complication of human immunodeficiency virus (HIV)-related opportunistic infections. Symptomatic raised cerebrospinal fluid pressure can be treated with ventriculoperitoneal shunt...

    Authors: James J. M. Loan, Ncedile Mankahla, Graeme Meintjes and A. Graham Fieggen

    Citation: Systematic Reviews 2017 6:201

    Content type: Protocol

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  26. It is estimated that 650,000 patients may develop human immunodeficiency virus (HIV)-related renal disease in South Africa. South Africa has recently adopted WHO policy, stipulating that all HIV-infected patie...

    Authors: Shirelle Assaram, Nombulelo P. Magula, Suman Mewa Kinoo and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2017 6:200

    Content type: Research

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  27. Chronic musculoskeletal pain is a major public health problem. Early prediction for optimal treatment results has received growing attention, but there is presently a lack of evidence regarding what informatio...

    Authors: Elena Tseli, Wilhelmus Johannes Andreas Grooten, Britt-Marie Stålnacke, Katja Boersma, Paul Enthoven, Björn Gerdle and Björn Olov Äng

    Citation: Systematic Reviews 2017 6:199

    Content type: Protocol

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  28. The onset of bathing disability for older adults has been found to be an indicator and potential precursor of further disability. Thus interventions targeting bathing may prevent or delay further disability an...

    Authors: Miriam Golding-Day, Phillip Whitehead, Kathryn Radford and Marion Walker

    Citation: Systematic Reviews 2017 6:198

    Content type: Research

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  29. The aim of this systematic review with meta-analysis was to analyze the effects of intra-pregnancy nonsurgical periodontal therapy on periodontal inflammatory biomarkers and adverse pregnancy outcomes.

    Authors: Helbert Eustáquio Cardoso da Silva, Cristine Miron Stefani, Nilce de Santos Melo, Adriano de Almeida de Lima, Cassiano Kuchenbecker Rösing, André Luís Porporatti and Graziela De Luca Canto

    Citation: Systematic Reviews 2017 6:197

    Content type: Research

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  30. Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is an aggressive disease that makes up about 20% of all invasive breast cancers. HER2+ breast cancer is associated with poor prognosis an...

    Authors: Florence R. Wilson, Megan E. Coombes, Quinlan Wylie, Mariya Yurchenko, Christine Brezden-Masley, Brian Hutton, Becky Skidmore and Chris Cameron

    Citation: Systematic Reviews 2017 6:196

    Content type: Protocol

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  31. Syphilis infection has recently resurfaced as a significant public health problem. Although there has been a tremendous amount of research on the epidemiology of syphilis, there has been limited work done to s...

    Authors: Ken Kitayama, Eddy R. Segura, Jordan E. Lake, Amaya G. Perez-Brumer, Catherine E. Oldenburg, Bethany A. Myers, Paria Pourjavaheri, Chinomnso N. Okorie, Robinson L. Cabello and Jesse L. Clark

    Citation: Systematic Reviews 2017 6:195

    Content type: Protocol

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  32. This study is to perform a systematic review of existing guidance on quality of reporting and methodology for systematic reviews of diagnostic test accuracy (DTA) in order to compile a list of potential items ...

    Authors: Trevor A. McGrath, Mostafa Alabousi, Becky Skidmore, Daniël A. Korevaar, Patrick M. M. Bossuyt, David Moher, Brett Thombs and Matthew D. F. McInnes

    Citation: Systematic Reviews 2017 6:194

    Content type: Research

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  33. Mobile health (mHealth) interventions for smoking cessation have been shown to be associated with an increase in effectiveness. However, interventions using mobile phones to change people’s behaviour are often...

    Authors: Pritaporn Kingkaew, Liz Glidewell, Rebecca Walwyn, Hamish Fraser and Jeremy C. Wyatt

    Citation: Systematic Reviews 2017 6:193

    Content type: Protocol

    Published on:

  34. The health of older persons has not been a major priority in many African countries. Hypertension is one of the common health problems of older persons. However, there is little information on the prevalence o...

    Authors: William K. Bosu, Justice M. K. Aheto, Eugenio Zucchelli and Siobhan Reilly

    Citation: Systematic Reviews 2017 6:192

    Content type: Protocol

    Published on:

  35. Out-of-hospital cardiac arrest (OHCA) is associated with significant mortality or may have a poor neurological outcome. Various community-training programmes have improved practices like bystander cardiopulmon...

    Authors: Leanne Eveson, Marcela Vizcaychipi and Shashank Patil

    Citation: Systematic Reviews 2017 6:191

    Content type: Protocol

    Published on:

  36. Numerous psychological risk and protective factors have been identified as contributing to or preventing the development of the prevalent issue of chronic pain. Systematic reviews of studies on psychological i...

    Authors: Mélanie Bérubé, Céline Gélinas, Manon Choinière, Nancy Feeley, Géraldine Martorella, Stefan Parent and David L. Streiner

    Citation: Systematic Reviews 2017 6:190

    Content type: Protocol

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  37. Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may...

    Authors: Ferrán Catalá-López, Brian Hutton, Matthew J. Page, Manuel Ridao, Jane A. Driver, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia and Rafael Tabarés-Seisdedos

    Citation: Systematic Reviews 2017 6:189

    Content type: Protocol

    Published on:

  38. Myopia is a common visual disorder with increasing prevalence among developed countries of the world. Myopia constitutes a substantial risk factor for several ocular conditions that can lead to blindness. The ...

    Authors: Efthymia Prousali, Asimina Mataftsi, Nikolaos Ziakas, Andreas Fontalis, Periklis Brazitikos and Anna-Bettina Haidich

    Citation: Systematic Reviews 2017 6:188

    Content type: Protocol

    Published on:

  39. Despite the growing appreciation of the importance of sex and gender considerations in transplantation research, there is currently no framework or good practice guidelines for the appropriate handling of sex ...

    Authors: Claudie Laprise, Vikas Srinivasan Sridhar, Lori West, Bethany Foster, Louise Pilote and Ruth Sapir-Pichhadze

    Citation: Systematic Reviews 2017 6:186

    Content type: Protocol

    Published on:

  40. While many outcomes post-stroke (e.g., depression) have been previously investigated, there is no complete data on the impact of a variety of quality improvement strategies on the quality of life and physical ...

    Authors: Sarah E.P. Munce, Laure Perrier, Saeha Shin, Chamila Adhihetty, Kristen Pitzul, Michelle L.A. Nelson and Mark T. Bayley

    Citation: Systematic Reviews 2017 6:184

    Content type: Protocol

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  41. Prevalence of non-communicable diseases has been increasing at a greater pace in developing countries and, in particular, the South Asia region. Various behavioral, social and environmental factors present in ...

    Authors: Sudesh Raj Sharma, Shiva Raj Mishra, Kusum Wagle, Rachel Page, Anna Matheson, Danielle Lambrick, James Faulkner, David Lounsbury and Abhinav Vaidya

    Citation: Systematic Reviews 2017 6:183

    Content type: Protocol

    Published on:

  42. Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in patients with dementia. Both pharmacological and non-pharmacological strategies are commonly used to treat these symptoms, but t...

    Authors: Jennifer Watt, Zahra Goodarzi, Andrea C. Tricco, Areti-Angeliki Veroniki and Sharon E. Straus

    Citation: Systematic Reviews 2017 6:182

    Content type: Protocol

    Published on:

  43. The clinical specialty of obstetrics is under particular scrutiny with increasing litigation costs and unnecessary tests and procedures done in attempts to prevent litigation. We aimed to identify reports eval...

    Authors: Roberta Cardoso, Wasifa Zarin, Vera Nincic, Sarah Louise Barber, Ahmet Metin Gulmezoglu, Charlotte Wilson, Katherine Wilson, Heather McDonald, Meghan Kenny, Rachel Warren, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2017 6:181

    Content type: Research

    Published on:

  44. Excess body weight and risky alcohol consumption are two of the greatest contributors to global disease. Health behaviours cluster in adolescence and track to adulthood. Very little is known about similar and ...

    Authors: Stephanie Scott, Jessica Reilly, Emma L. Giles, Frances Hillier-Brown, Louisa Ells, Eileen Kaner and Ashley Adamson

    Citation: Systematic Reviews 2017 6:180

    Content type: Protocol

    Published on:

  45. Many medical residents lack ready access to social and emotional supports that enable them to successfully cope with the challenges associated with medical residency. This absence of support has been shown to ...

    Authors: Helen Pethrick, Lorelli Nowell, Elizabeth Oddone Paolucci, Liza Lorenzetti, Michele Jacobsen, Tracey Clancy and Diane L. Lorenzetti

    Citation: Systematic Reviews 2017 6:178

    Content type: Protocol

    Published on:

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