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  1. Content type: Protocol

    Improved life expectancy is resulting in increased outpatient treatment of people with chronic physical health conditions and reliance on the provision of informal care in the community. However, informal care...

    Authors: Joanne Woodford, Paul Farrand, David Richards and David J Llewellyn

    Citation: Systematic Reviews 2013 2:9

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  2. Content type: Protocol

    Inflammatory bowel disease is an idiopathic chronic disease that affects around 28 million people worldwide. Symptoms are distressing and have a detrimental effect on patients’ quality of life. A possible link...

    Authors: Mariyana Schoultz, Iain Atherton, Gill Hubbard and Angus JM Watson

    Citation: Systematic Reviews 2013 2:8

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  3. Content type: Methodology

    The Beta-Blockers in Heart Failure Collaborative Group (BB-HF) was formed to obtain and analyze individual patient data from the major randomized controlled trials of beta-blockers in heart failure. Even thoug...

    Authors: Dipak Kotecha, Luis Manzano, Douglas G Altman, Henry Krum, Guliz Erdem, Nicola Williams and Marcus D Flather

    Citation: Systematic Reviews 2013 2:7

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  4. Content type: Protocol

    In 2010, there were approximately 8.8 million incident cases of tuberculosis (TB) worldwide. The treatment of TB is at least six months long and may be complicated by a high pill burden. In addition, TB patien...

    Authors: Mweete D Nglazi, Linda-Gail Bekker, Robin Wood, Gregory D Hussey and Charles S Wiysonge

    Citation: Systematic Reviews 2013 2:6

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  5. Content type: Research

    Many reports point to the beneficial effect of male partner involvement in programs for the prevention of mother-to-child-transmission (PMTCT) of HIV in curbing pediatric HIV infections. This paper summarizes ...

    Authors: Frederick Morfaw, Lawrence Mbuagbaw, Lehana Thabane, Clarissa Rodrigues, Ana-Paula Wunderlich, Philip Nana and John Kunda

    Citation: Systematic Reviews 2013 2:5

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  6. Content type: Research

    PROSPERO, an international prospective register of systematic review protocols in health and social care, was launched in February 2011. After one year of operation we describe access and use, explore user exp...

    Authors: Alison Booth, Mike Clarke, Gordon Dooley, Davina Ghersi, David Moher, Mark Petticrew and Lesley Stewart

    Citation: Systematic Reviews 2013 2:4

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  7. Content type: Research

    Problem alcohol use is common among illicit drug users and is associated with adverse health outcomes. It is also an important factor in poor prognosis among drug users with hepatitis C virus (HCV) as it impac...

    Authors: Jan Klimas, Catherine-Anne Field, Walter Cullen, Clodagh SM O’Gorman, Liam G Glynn, Eamon Keenan, Jean Saunders, Gerard Bury and Colum Dunne

    Citation: Systematic Reviews 2013 2:3

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  8. Content type: Protocol

    Methodological research has found that non-published studies often have different results than those that are published, a phenomenon known as publication bias. When results are not published, or are published...

    Authors: Susan Portalupi, Erik von Elm, Christine Schmucker, Britta Lang, Edith Motschall, Guido Schwarzer, Isabel T Gross, Roberta W Scherer, Dirk Bassler and Joerg J Meerpohl

    Citation: Systematic Reviews 2013 2:2

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  9. Content type: Research

    An automated dose dispensing (ADD) service has been implemented in primary healthcare in some European countries. In this service, regularly used medicines are machine-packed into unit-dose bags for each time ...

    Authors: Juha Sinnemäki, Sinikka Sihvo, Jaana Isojärvi, Marja Blom, Marja Airaksinen and Antti Mäntylä

    Citation: Systematic Reviews 2013 2:1

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  10. Content type: Methodology

    Pulmonary rehabilitation (PR) and self-management (SM) support programmes are effective in the management of patients with chronic obstructive pulmonary disease (COPD), but these interventions are not widely i...

    Authors: Ratna Sohanpal, Richard Hooper, Rachel Hames, Stefan Priebe and Stephanie Taylor

    Citation: Systematic Reviews 2012 1:66

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  11. Content type: Protocol

    Influenza is an acute respiratory illness caused by influenza viruses, which occurs in epidemics worldwide every year. Children are an important target for prevention methods, including vaccination. While evid...

    Authors: Gabriela J Prutsky, Juan Pablo Domecq, Tarig Elraiyah, Zhen Wang, Lisa A Grohskopf, Larry J Prokop, Victor M Montori and Mohammad Hassan Murad

    Citation: Systematic Reviews 2012 1:65

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  12. Content type: Protocol

    Low back pain (LBP) is one of the leading causes of disability and has a major socioeconomic impact. Despite a large amount of research in the field, there remains uncertainty about the best treatment approach...

    Authors: Jill A Hayden, Jennifer L Cartwright, Richard D Riley and Maurits W vanTulder

    Citation: Systematic Reviews 2012 1:64

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  13. Content type: Protocol

    In patients undergoing open cardiothoracic and upper abdominal surgery, postoperative pulmonary complications remain an important cause of postoperative morbidity and mortality, impacting upon hospital length ...

    Authors: Christina M Mans, Julie C Reeve, Catherine A Gasparini and Mark R Elkins

    Citation: Systematic Reviews 2012 1:63

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  14. Content type: Systematic review update

    The aim of this systematic review was to systematically assess the potential patient-relevant benefit (primary aim) and diagnostic and prognostic accuracy (secondary aim) of positron emission tomography (PET) ...

    Authors: Milly A Schröer-Günther, Robert F Wolff, Marie E Westwood, Fülöp J Scheibler, Christoph Schürmann, Brigitta G Baumert, Stefan Sauerland and Jos Kleijnen

    Citation: Systematic Reviews 2012 1:62

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  15. Content type: Protocol

    Neuropathic pain can reduce the quality of life and independence of 30% to 50% of patients with diabetes. The comparative effectiveness of analgesics for patients with diabetic neuropathy remains unclear. The ...

    Authors: Marcio L Griebeler, Apostolos Tsapas, Juan P Brito, Zhen Wang, Olivia J Phung, Victor M Montori and M Hassan Murad

    Citation: Systematic Reviews 2012 1:61

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  16. Content type: Research

    The Consolidated Standards of Reporting Trials (CONSORT) Statement is intended to facilitate better reporting of randomised clinical trials (RCTs). A systematic review recently published in the Cochrane Librar...

    Authors: Lucy Turner, Larissa Shamseer, Douglas G Altman, Kenneth F Schulz and David Moher

    Citation: Systematic Reviews 2012 1:60

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  17. Content type: Protocol

    Setting priorities for the prevention and management of heart failure requires an empirical understanding of the pattern of disease burden. We aim to describe the methods for a systematic review of the literat...

    Authors: Derrick A Bennett, Thomas K Eliasz, Anna Forbes, Alastair Kiszely, Rajit Khosla, Tatjana Petrinic, Devarsetty Praveen, Roohi Shrivastava, Du Xin, Anushka Patel, Stephen MacMahon and Kazem Rahimi

    Citation: Systematic Reviews 2012 1:59

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  18. Content type: Research

    Immigrants from developing and middle-income countries are an emerging priority in HIV prevention in high-income countries. This may be explained in part by accelerating international migration and population ...

    Authors: Tadgh McMahon and Paul R Ward

    Citation: Systematic Reviews 2012 1:56

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  19. Content type: Research

    Studies have reported an impact of central obesity on people’s health. The literature is scarce on the effects of waist circumference (WC) on pulmonary function. Our objective was to review the literature on t...

    Authors: Fernando César Wehrmeister, Ana Maria Baptista Menezes, Ludmila Correa Muniz, Jeovany Martínez-Mesa, Marlos Rodrigues Domingues and Bernardo Lessa Horta

    Citation: Systematic Reviews 2012 1:55

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  20. Content type: Protocol

    Patients’ expectations of treatment effects may contribute to positive (placebo) and negative (nocebo) outcomes. The effect of patient expectations may be pronounced in subjectively assessed conditions, such a...

    Authors: Frederik Feys, Geertruida E Bekkering, Kavita Singh and Dirk Devroey

    Citation: Systematic Reviews 2012 1:54

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  21. Content type: Protocol

    There is concern that some veterans of armed forces, in particular those with mental health, drug or alcohol problems, experience difficulty returning to a civilian way of life and may subsequently come into c...

    Authors: James Taylor, Tessa Parkes, Sally Haw and Ruth Jepson

    Citation: Systematic Reviews 2012 1:53

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  22. Content type: Protocol

    The enhanced recovery after surgery (ERAS) programme is a multimodal evidence-based approach to surgical care which begins in the preoperative setting and extends through to patient discharge in the postoperat...

    Authors: Lesley Gotlib Conn, Ori D Rotstein, Elisa Greco, Andrea C Tricco, Laure Perrier, Charlene Soobiah and Tony Moloney

    Citation: Systematic Reviews 2012 1:52

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  23. Content type: Protocol

    The use of financial incentives and penalties to encourage uptake of healthy behaviors is increasingly seen as a viable intervention in developed countries. Previous reviews of the effectiveness of financial i...

    Authors: Jean Adams, Emma L Giles, Shannon Robalino, Elaine McColl and Falko F Sniehotta

    Citation: Systematic Reviews 2012 1:51

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  24. Content type: Commentary

    Systematic reviewers are increasingly trying to obtain regulatory clinical study reports (CSRs) to correct for publication bias. For instance, our organization, the Institute for Quality and Efficiency in Heal...

    Authors: Beate Wieseler, Natalie McGauran, Michaela F Kerekes and Thomas Kaiser

    Citation: Systematic Reviews 2012 1:50

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  25. Content type: Research

    Accessible sexual, reproductive, and mental healthcare services are crucial for adolescent health and wellbeing. It has been reported that school-based healthcare (SBHC) has the potential to improve the availa...

    Authors: Amanda J Mason-Jones, Carolyn Crisp, Mariette Momberg, Joy Koech, Petra De Koker and Cathy Mathews

    Citation: Systematic Reviews 2012 1:49

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  26. Content type: Protocol

    School-based interventions and campaigns are used to promote health and address a wide variety of public health problems. Schools are considered to be key sites for the implementation of health promotion progr...

    Authors: Mark Pearson, Roy Chilton, Helen B Woods, Katrina Wyatt, Tamsin Ford, Charles Abraham and Rob Anderson

    Citation: Systematic Reviews 2012 1:48

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  27. Content type: Protocol

    Diabetes and increased age are known risk factors for physical disability. With the increasing prevalence of diabetes within our aging population, the future burden of disability is expected to increase. To da...

    Authors: Evelyn Wong, Kathryn Backholer, Jessica Harding, Emma Gearon, Christopher Stevenson, Rosanne Freak-Poli and Anna Peeters

    Citation: Systematic Reviews 2012 1:47

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  28. Content type: Research

    Co-morbid symptoms (for example, chronic pain, depression, anxiety, and fatigue) are particularly common in military fighters returning from the current conflicts, who have experienced physical and/or psycholo...

    Authors: Courtney Lee, Cindy Crawford, Dawn Wallerstedt, Alexandra York, Alaine Duncan, Jennifer Smith, Meredith Sprengel, Richard Welton and Wayne Jonas

    Citation: Systematic Reviews 2012 1:46

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  29. Content type: Protocol

    Older adults experience activity and participation limitations that are associated with ageing. Activity and participation limitations affect an older adult’s ability to engage in meaningful daily activities a...

    Authors: Kylie Wales, Lindy Clemson, Natasha A Lannin and Ian D Cameron

    Citation: Systematic Reviews 2012 1:45

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  30. Content type: Protocol

    Many drugs and treatments given to patients for various reasons affect their weight. This side effect is of great importance to patients and is also a concern for the treating physician because weight change m...

    Authors: Juan Pablo Domecq, Gabriela Prutsky, Zhen Wang, Tarig Elraiyah, Juan Pablo Brito, Karen Mauck, Mohammed H Lababidi, Aaron Leppin, Salman Fidahussein, Larry J Prokop, Victor M Montori and Mohammad H Murad

    Citation: Systematic Reviews 2012 1:44

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  31. Content type: Research

    All randomized clinical trials (RCTs) require a protocol; however, numerous studies have highlighted protocol deficiencies. Reporting guidelines may improve the content of research reports and, if developed us...

    Authors: Jennifer M Tetzlaff, An-Wen Chan, Jessica Kitchen, Margaret Sampson, Andrea C Tricco and David Moher

    Citation: Systematic Reviews 2012 1:43

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  32. Content type: Research

    The role of intravascular ultrasound (IVUS) in percutaneous coronary interventions (PCI) is still controversial despite several previously published meta-analyses. A meta-analysis to evaluate the controversial...

    Authors: Lucas Lodi-Junqueira, Marcos Roberto de Sousa, Leonardo Carvalho da Paixão, Silvana Márcia Bruschi Kelles, Carlos Faria Santos Amaral and Antonio L Ribeiro

    Citation: Systematic Reviews 2012 1:42

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  33. Content type: Methodology

    Network meta-analysis is becoming increasingly popular for establishing comparative effectiveness among multiple interventions for the same disease. Network meta-analysis inherits all methodological challenges...

    Authors: Kristian Thorlund and Edward J Mills

    Citation: Systematic Reviews 2012 1:41

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  34. Content type: Protocol

    Perioperative pain management has recently been revolutionized with the recognition of novel mechanisms and introduction of newer drugs. Many randomized trials have studied the use of the gabapentinoid anti-ep...

    Authors: Naveen Eipe, John Penning, Mohammed Ansari, Fatemeh Yazdi and Nadera Ahmadzai

    Citation: Systematic Reviews 2012 1:40

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  35. Content type: Research

    Recent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the va...

    Authors: Sanjin Alajbegovic, John W Sanders, Deborah E Atherly and Mark S Riddle

    Citation: Systematic Reviews 2012 1:39

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  36. Content type: Research

    Systematic reviews are promoted as being important to inform decision-making. However, when presented with a set of reviews in a complex area, how easy is it to understand how and why they may differ from one ...

    Authors: Jenny Woodman, James Thomas and Kelly Dickson

    Citation: Systematic Reviews 2012 1:37

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  37. Content type: Systematic review update

    The purpose of this project was to conduct an overview of existing systematic reviews to evaluate the effectiveness of reminders in changing professional behavior in clinical settings.

    Authors: Amy Cheung, Michelle Weir, Alain Mayhew, Nicole Kozloff, Kaitlyn Brown and Jeremy Grimshaw

    Citation: Systematic Reviews 2012 1:36

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  38. Content type: Protocol

    Influenza vaccines are most effective when the antigens in the vaccine match those of circulating influenza strains. The extent to which the vaccine is protective when circulating strains differ from vaccine a...

    Authors: Andrea C Tricco, Ayman Chit, David Hallett, Charlene Soobiah, Genevieve Meier, Maggie Chen, Mariam Tashkandi, Chris Bauch and Mark Loeb

    Citation: Systematic Reviews 2012 1:35

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  39. Content type: Research

    Hyperprolactinemia is a common endocrine disorder that can be associated with significant morbidity. We conducted a systematic review and meta-analyses of outcomes of hyperprolactinemic patients, including mic...

    Authors: Amy T Wang, Rebecca J Mullan, Melanie A Lane, Ahmad Hazem, Chaithra Prasad, Nicola W Gathaiya, M Mercè Fernández-Balsells, Amy Bagatto, Fernando Coto-Yglesias, Jantey Carey, Tarig A Elraiyah, Patricia J Erwin, Gunjan Y Gandhi, Victor M Montori and Mohammad Hassan Murad

    Citation: Systematic Reviews 2012 1:33

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  40. Content type: Protocol

    Approximately 35 million people world-wide have Alzheimer’s disease and this is projected to nearly double by 2030. Cognitive enhancers, including cholinesterase inhibitors (for example, donepezil, galantamine...

    Authors: Andrea C Tricco, Sondra vanderVaart, Charlene Soobiah, Erin Lillie, Laure Perrier, Maggie H Chen, Brenda Hemmelgarn, Sumit R Majumdar and Sharon E Straus

    Citation: Systematic Reviews 2012 1:31

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  41. Content type: Research

    High rates of childhood maltreatment have been documented in HIV-positive men and women. In addition, mental disorders are highly prevalent in both HIV-infected individuals and victims of childhood maltreatmen...

    Authors: Georgina Spies, Tracie O Afifi, Sarah L Archibald, Christine Fennema-Notestine, Jitender Sareen and Soraya Seedat

    Citation: Systematic Reviews 2012 1:30

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  42. Content type: Commentary

    This paper argues that the current proliferation of types of systematic reviews creates challenges for the terminology for describing such reviews. Terminology is necessary for planning, describing, appraising...

    Authors: David Gough, James Thomas and Sandy Oliver

    Citation: Systematic Reviews 2012 1:28

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  43. Content type: Protocol

    Canada’s diverse society and statutory commitment to multiculturalism means that the synthesis of knowledge related to the health care experiences of immigrants is essential to realize the health potential for...

    Authors: Gina M A Higginbottom, Myfanwy Morgan, Jayantha Dassanayake, Helgi Eyford, Mirande Alexandre, Yvonne Chiu, Joan Forgeron and Deb Kocay

    Citation: Systematic Reviews 2012 1:27

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  44. Content type: Research

    The objective of this systematic review was to examine the benefits, harms and pharmacokinetic interactions arising from the co-administration of commonly used dietary supplements with cardiovascular drugs. Ma...

    Authors: Salmaan Kanji, Dugald Seely, Fatemeh Yazdi, Jennifer Tetzlaff, Kavita Singh, Alexander Tsertsvadze, Andrea C Tricco, Margaret E Sears, Teik C Ooi, Michele A Turek, Becky Skidmore and Mohammed T Ansari

    Citation: Systematic Reviews 2012 1:26

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