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  1. There is considerable interest in the impact of increased flavan-3-ol intake on cardiovascular disease (CVD) and diabetes outcomes. Through evidence mapping, we determined the extent of the evidence base to in...

    Authors: Gowri Raman, Marissa Shams-White, Esther E. Avendano, Fan Chen, Janet A. Novotny and Aedin Cassidy
    Citation: Systematic Reviews 2018 7:100
    Content type: Research Published on:

  3. Glucose abnormalities in cystic fibrosis (CF) are common, but there is limited evidence to guide their dietary management. Progressive impaired glucose tolerance eventually leads to cystic fibrosis-related dia...

    Authors: Laura Birch, Fiona E. Lithander, Simon Langton Hewer, Katie Harriman, Julian Hamilton-Shield and Rachel Perry
    Citation: Systematic Reviews 2018 7:98
    Content type: Protocol Published on:

  4. When patients have been on opioid therapy for more than 90 days, more than half of them continue using opioids years later. Knowing that long-term opioid consumption could lead to harmful side effects includin...

    Authors: M. Gabrielle Pagé, Irina Kudrina, Hervé Tchala Vignon Zomahoun, Daniela Ziegler, Pierre Beaulieu, Céline Charbonneau, Jennifer Cogan, Raoul Daoust, Marc O. Martel, Andrée Néron, Philippe Richebé and Hance Clarke
    Citation: Systematic Reviews 2018 7:97
    Content type: Protocol Published on:

  5. Diabetes mellitus (DM) in women of childbearing age may affect the fetus, thereby accelerating the intergenerational risk of DM. The Middle East and North Africa (MENA) region is experiencing a growing epidemi...

    Authors: Rami H. Al-Rifai and Faisal Aziz
    Citation: Systematic Reviews 2018 7:96
    Content type: Protocol Published on:

  6. Pediatric epilepsy, including treatment-resistant forms, has a major effect on the quality of life, morbidity, and mortality of affected children. Interest has been growing in the use of medical cannabis as a ...

    Authors: Jesse Elliott, Deirdre DeJean, Tammy Clifford, Doug Coyle, Beth Potter, Becky Skidmore, Christine Alexander, Alexander E. Repetski, Bláthnaid McCoy and George A. Wells
    Citation: Systematic Reviews 2018 7:95
    Content type: Protocol Published on:

  7. Systematic review (SR) guidelines recommend extending literature search to gray literature in order to identify all available data related to the review topic. We aim to conduct an overview of SRs on populatio...

    Authors: Karima Chaabna, Sohaila Cheema, Amit Abraham, Hekmat Alrouh, Ravinder Mamtani and Javaid I. Sheikh
    Citation: Systematic Reviews 2018 7:94
    Content type: Protocol Published on:

  8. ‘Pain rewarded’ is a hypothesis wherein acute pain sufferers are exposed to reinforcers and punishers from their environment that shape their behaviour, i.e. pain responses. Such a point of view has been taken...

    Authors: Wacław M. Adamczyk, Kerstin Luedtke, Ewa Buglewicz and Przemysław Bąbel
    Citation: Systematic Reviews 2018 7:93
    Content type: Protocol Published on:

  9. As general population life expectancy has increased, the need to investigate the quality of life has arisen, especially because it is important that people have a healthy long life and with good quality. Studi...

    Authors: Janete Capel Hernandes, Viviane Cruvinel Di Castro, Mauro Elias Mendonça and Celmo Celeno Porto
    Citation: Systematic Reviews 2018 7:92
    Content type: Protocol Published on:

  10. Dementia is a globally prevalent disease that requires ongoing and increasing levels of care, often provided in the first instance by informal caregivers. Supporting transitions in informal caregiving in demen...

    Authors: Marianne Cranwell, Anna Gavine, Linda McSwiggan and Timothy B. Kelly
    Citation: Systematic Reviews 2018 7:91
    Content type: Protocol Published on:

  11. Individuals with substance use and addictive disorders often display greater risk-taking behaviour, higher impulsivity, and altered reward processing compared to individuals without these disorders. While it i...

    Authors: Katherine R. Naish, Lana Vedelago, James MacKillop and Michael Amlung
    Citation: Systematic Reviews 2018 7:90
    Content type: Protocol Published on:

  12. Neoadjuvant chemotherapy (NACT), a standard of care for locally advanced breast cancer patients, is widely used for early breast cancer patients also. The varying role of regimens used as NACT needs to be inve...

    Authors: Mona Pathak, Sada Nand Dwivedi, S. V. S. Deo, Bhaskar Thakur, Vishnubhatla Sreenivas and G. K. Rath
    Citation: Systematic Reviews 2018 7:89
    Content type: Protocol Published on:

  13. Menu labelling is continuing to gather public and legislative support as one of the potential environmental strategies for addressing the obesity pandemic. However, issues relating to implementation have been ...

    Authors: Claire Kerins, Jennifer McSharry, Catherine Hayes, Ivan J. Perry, Fiona Geaney and Colette Kelly
    Citation: Systematic Reviews 2018 7:88
    Content type: Protocol Published on:

  14. The journal recently celebrated its fifth anniversary. Like systematic reviews themselves, the journal is thriving and publishing a variety of protocols, reviews, and methods papers. We have also had success i...

    Authors: David Moher, Lesley A. Stewart and Paul Shekelle
    Citation: Systematic Reviews 2018 7:87
    Content type: Editorial Published on:

  15. Meningococcal disease (MD) is notoriously difficult to diagnose in the early stages of the illness and presents similarly to many self-limiting viral infections. This mandates a cautious approach to diagnosis ...

    Authors: Thomas Waterfield, Derek Fairley, Fiona Lynn, Bronagh Blackwood and Michael D. Shields
    Citation: Systematic Reviews 2018 7:86
    Content type: Protocol Published on:

  16. Systematic reviews (SRs) of randomised controlled trials (RCTs) can provide the best evidence to inform decision-making, but their methodological and reporting quality varies. Tools exist to guide the critical...

    Authors: Allison Gates, Michelle Gates, Gonçalo Duarte, Maria Cary, Monika Becker, Barbara Prediger, Ben Vandermeer, Ricardo M. Fernandes, Dawid Pieper and Lisa Hartling
    Citation: Systematic Reviews 2018 7:85
    Content type: Protocol Published on:

  17. Self-management support interventions may potentially delay kidney function decline and associated complications in patients with comorbid diabetes and chronic kidney disease. However, the effectiveness of the...

    Authors: Edward Zimbudzi, Clement Lo, Marie L. Misso, Sanjeeva Ranasinha, Peter G. Kerr, Helena J. Teede and Sophia Zoungas
    Citation: Systematic Reviews 2018 7:84
    Content type: Research Published on:

  18. Non-infectious uveitis represents a sub-type of intraocular inflammation often associated with disorders of immune dysregulation. If untreated, the intraocular inflammation may progress to severe visual impair...

    Authors: Joshua Blair, Robert Barry, Philip I. Murray, David J. Moore and Alastair K. Denniston
    Citation: Systematic Reviews 2018 7:83
    Content type: Protocol Published on:

  19. Early diagnosis of human immunodeficiency virus (HIV) is important because antiretroviral therapies are more effective if infected individuals are diagnosed early. Diagnosis of HIV relies on laboratory testing...

    Authors: Benhildah N. Rumbwere Dube, Tom P. Marshall, Ronan P. Ryan and Modupe Omonijo
    Citation: Systematic Reviews 2018 7:82
    Content type: Research Published on:

  20. Of various chronic diseases, low back pain (LBP) is the most common and debilitating musculoskeletal condition among older adults aged 65 years or older. While more than 17 million older adults in the USA suff...

    Authors: Arnold Y. L. Wong, Katarina Sjögren Forss, Jenny Jakobsson, Veronika Schoeb, Christine Kumlien and Gunilla Borglin
    Citation: Systematic Reviews 2018 7:81
    Content type: Protocol Published on:

  21. Anemia continued to become a major public health problem in developing nations including Ethiopia. Especially, school children are more vulnerable for anemia and consequences of anemia. Generating accurate epi...

    Authors: Robel Tezera, Zekariyas Sahile, Delelegn Yilma, Equilnet Misganaw and Ermiyas Mulu
    Citation: Systematic Reviews 2018 7:80
    Content type: Research Published on:

  22. Conducting a health technology assessment (HTA) of public health interventions (PHIs) poses some challenges. PHIs are often complex interventions, which affect the number and degree of interactions of the aspe...

    Authors: Tim Mathes, Gerald Willms, Stephanie Polus, Constance Stegbauer, Melanie Messer, Corinna Klingler, Heidi Ehrenreich, Dea Niebuhr, Georg Marckmann, Ansgar Gerhardus and Dawid Pieper
    Citation: Systematic Reviews 2018 7:79
    Content type: Protocol Published on:

  23. Needle-related procedures are the most important source of pain in children in hospital setting. Unmanaged pain could result in short- and long-term physiological, psychological, and emotional consequences. Al...

    Authors: Ariane Ballard, Christelle Khadra, Samara Adler, Evelyne Doyon-Trottier and Sylvie Le May
    Citation: Systematic Reviews 2018 7:78
    Content type: Protocol Published on:

  24. Systematic reviews (SR) are vital to health care, but have become complicated and time-consuming, due to the rapid expansion of evidence to be synthesised. Fortunately, many tasks of systematic reviews have th...

    Authors: Elaine Beller, Justin Clark, Guy Tsafnat, Clive Adams, Heinz Diehl, Hans Lund, Mourad Ouzzani, Kristina Thayer, James Thomas, Tari Turner, Jun Xia, Karen Robinson and Paul Glasziou
    Citation: Systematic Reviews 2018 7:77
    Content type: Commentary Published on:

  25. Adult brachial plexus injuries (BPI) are becoming more common. The reconstruction and prognosis of pre-ganglionic injuries (root avulsions) are different to other types of BPI injury. Preoperative magnetic res...

    Authors: Ryckie G. Wade, Yemisi Takwoingi, Justin C. R. Wormald, John P. Ridgway, Steven Tanner, James J. Rankine and Grainne Bourke
    Citation: Systematic Reviews 2018 7:76
    Content type: Protocol Published on:

  26. There will be a lack of 18 million healthcare workers by 2030. Multiplying the number of well-trained healthcare workers through innovative ways such as eLearning is highly recommended in solving this shortage...

    Authors: Gloria C. Law, Christian Apfelbacher, Pawel P. Posadzki, Sandra Kemp and Lorainne Tudor Car
    Citation: Systematic Reviews 2018 7:75
    Content type: Protocol Published on:

  27. Hearing loss is one of the leading causes of disability worldwide, with greater than 20% of Canadian adults having measurable hearing loss in at least one ear. Patients with hearing loss experience impaired qu...

    Authors: Nadera Ahmadzai, Shaun Kilty, Dianna Wolfe, Jamie Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Wei Cheng, Becky Skidmore, David Moher and Brian Hutton
    Citation: Systematic Reviews 2018 7:74
    Content type: Protocol Published on:

  28. Exertional lower body musculoskeletal injuries (ELBI) cost billions of dollars and compromise the readiness and job performance of military service and public safety workers (i.e., tactical populations). The p...

    Authors: Shawn D. Flanagan, Aaron M. Sinnott, Kellen T. Krajewski, Caleb D. Johnson, Shawn R. Eagle, Alice D. LaGoy, Meaghan E. Beckner, Anne Z. Beethe, Rose Turner, Mita Lovalekar, Courtenay Dunn-Lewis, Chris Connaboy and Bradley C. Nindl
    Citation: Systematic Reviews 2018 7:73
    Content type: Protocol Published on:

  29. Organizational contextual features have been recognized as important determinants for implementing evidence-based practices across healthcare settings for over a decade. However, implementation scientists have...

    Authors: Shelly-Anne Li, Lianne Jeffs, Melanie Barwick and Bonnie Stevens
    Citation: Systematic Reviews 2018 7:72
    Content type: Research Published on:

  30. Pharmacist counselling is an important service that has been associated with improved outcomes. The primary aim of this review was to identify, describe, and determine the effectiveness of interventions for im...

    Authors: Sinaa Al Aqeel, Norah Abanmy, Hiba AlShaya and Albatoul Almeshari
    Citation: Systematic Reviews 2018 7:71
    Content type: Research Published on:

  31. Cryptosporidium is a protozoan parasite of humans and other animals worldwide and is one of the greatest contributors to human diarrhoeal illness. Transmission can occur indirectly via contaminated food or water,...

    Authors: Caoimhe McKerr, Sarah J. O’Brien, Rachel M. Chalmers, Roberto Vivancos and Robert M. Christley
    Citation: Systematic Reviews 2018 7:70
    Content type: Protocol Published on:

  32. To investigate the use of physical activity monitors (PAMs) for the elderly, the scientific literature should be systematically reviewed and the effect quantified, as the evidence seems inconclusive.

    Authors: Rasmus Tolstrup Larsen, Jan Christensen, Carsten Bogh Juhl, Henning Boje Andersen and Henning Langberg
    Citation: Systematic Reviews 2018 7:69
    Content type: Protocol Published on:

  33. Health information is readily accessible but is of variable quality. General knowledge about how to assess whether claims about health interventions are trustworthy is not common, so people’s health decisions ...

    Authors: Leila Cusack, Chris B. Del Mar, Iain Chalmers, Elizabeth Gibson and Tammy C. Hoffmann
    Citation: Systematic Reviews 2018 7:68
    Content type: Research Published on:

  34. People with a mental illness experience a higher morbidity and mortality from chronic diseases relative to the general population. A higher prevalence of risk behaviours, including tobacco smoking, poor nutrit...

    Authors: Caitlin Fehily, Kate Bartlem, John Wiggers, Luke Wolfenden, Timothy Regan, Julia Dray, Jacqueline Bailey and Jenny Bowman
    Citation: Systematic Reviews 2018 7:67
    Content type: Protocol Published on:

  35. Implementation science is the study of strategies used to integrate evidence-based practices into real-world settings (Eccles and Mittman, Implement Sci. 1(1):1, 2006). Central to the identification of replica...

    Authors: Cara C. Lewis, Kayne D. Mettert, Caitlin N. Dorsey, Ruben G. Martinez, Bryan J. Weiner, Elspeth Nolen, Cameo Stanick, Heather Halko and Byron J. Powell
    Citation: Systematic Reviews 2018 7:66
    Content type: Protocol Published on:

  36. Transportation interventions seek to decrease delay in reaching a health facility for emergency obstetric care and are, thus, believed to contribute to reductions in such adverse pregnancy and childbirth outco...

    Authors: John Ehiri, Halimatou Alaofè, Ibitola Asaolu, Joy Chebet, Ekpereonne Esu and Martin Meremikwu
    Citation: Systematic Reviews 2018 7:65
    Content type: Protocol Published on:

  38. Previous research shows that many authors of Cochrane overviews were also involved in some of the included systematic reviews (SRs). This type of dual (co-)authorship (DCA) may be a conflict of interest and a ...

    Authors: Dawid Pieper, Andreas Waltering, Jakob Holstiege and Roland Brian Büchter
    Citation: Systematic Reviews 2018 7:63
    Content type: Research Published on:

  39. In the context of rising dementia prevalence, the workload of general practitioners (GPs) in dementia care is set to increase. However, there are many aspects of dementia care that GPs find challenging. Behavi...

    Authors: Aisling A. Jennings, Tony Foley, Kieran A. Walsh, Alice Coffey, John P. Browne and Colin P. Bradley
    Citation: Systematic Reviews 2018 7:62
    Content type: Protocol Published on:

  40. Three types of central venous access devices (CVADs)—peripherally inserted central catheters (PICCs), skin-tunnelled central catheters (Hickman-type devices), and implantable chest wall Ports (Ports)—are routi...

    Authors: Caoimhe Ryan, Hannah Hesselgreaves, Olivia Wu, Jim Paul, Judith Dixon-Hughes and Jonathan G. Moss
    Citation: Systematic Reviews 2018 7:61
    Content type: Protocol Published on:

  41. Nearly 15% of all pregnancies end in fatal perinatal obstetric complications including bleeding, infections, hypertension, obstructed labor, and complications of abortion. Between 1990 and 2015, an estimated 1...

    Authors: Ayele Geleto, Catherine Chojenta, Abdulbasit Mussa and Deborah Loxton
    Citation: Systematic Reviews 2018 7:60
    Content type: Protocol Published on:

  42. We investigated whether information in ClinicalTrials.gov would impact the conclusions of five ongoing systematic reviews.

    Authors: Gaelen P. Adam, Stacey Springs, Thomas Trikalinos, John W. Williams Jr, Jennifer L. Eaton, Megan Von Isenburg, Jennifer M. Gierisch, Lisa M. Wilson, Karen A. Robinson, Meera Viswanathan, Jennifer Cook Middleton, Valerie L. Forman-Hoffman, Elise Berliner and Robert M. Kaplan
    Citation: Systematic Reviews 2018 7:59
    Content type: Research Published on:

  43. Mid-portion Achilles tendinopathy (AT) is prevalent amongst athletic and non-athletic populations with pain, stiffness and impaired function typically reported. While different management options exist, loadin...

    Authors: Myles Murphy, Mervyn Travers and William Gibson
    Citation: Systematic Reviews 2018 7:58
    Content type: Protocol Published on:

  44. Depression and anxiety symptoms are reported to be common among university students in many regions of the world and impact on quality of life and academic attainment. The extent of the problem of depression a...

    Authors: James January, Munyaradzi Madhombiro, Shalote Chipamaunga, Sunanda Ray, Alfred Chingono and Melanie Abas
    Citation: Systematic Reviews 2018 7:57
    Content type: Protocol Published on:

  45. Despite a decline in child and adult smoking prevalence, young people who smoke (even occasionally) can rapidly become addicted to nicotine, with most adult smokers initiating smoking before they are 18. Schoo...

    Authors: Fiona Dobbie, Kathryn Angus, Hannah Littlecott, Karen Allum, Valerie Wells, Amanda Amos, Sally Haw and Linda Bauld
    Citation: Systematic Reviews 2018 7:56
    Content type: Protocol Published on:

  46. The Sustainable Development Goal (SDG) 3 emphasises on reducing neonatal deaths caused by low birth weight (LBW) complications by the implementation and utilisation of Kangaroo Mother Care (KMC) in low- and mi...

    Authors: Christina T. Mathias, Solange Mianda and Themba G. Ginindza
    Citation: Systematic Reviews 2018 7:55
    Content type: Protocol Published on:

  47. Childhood obesity is a major global public health problem, with governments increasingly having to undertake various strategies to reduce excess weight in their populations. Considering the increasing number o...

    Authors: Mandana Zanganeh, Peymane Adab, Bai Li and Emma Frew
    Citation: Systematic Reviews 2018 7:54
    Content type: Protocol Published on:

  48. Caring for patients with subarachnoid hemorrhage (SAH) presents unique challenges, due in part to the severity of the underlying insult, competing systemic injuries, and unpredictable clinical course. Even whe...

    Authors: Shaurya Taran, Vatsal Trivedi, Jeffrey M. Singh, Shane W. English and Victoria A. McCredie
    Citation: Systematic Reviews 2018 7:53
    Content type: Protocol Published on:

  49. Heart failure (HF) in pediatric populations is a major public health concern. It is associated with high rates of hospital admissions, disability, and mortality in high-income countries (HIC), but its burden i...

    Authors: Aurélie T. Sibetcheu, Valirie Ndip Agbor, Ulrich Flore Nyaga, Jean Joël Bigna and Jean Jacques Noubiap
    Citation: Systematic Reviews 2018 7:52
    Content type: Protocol Published on:

  50. The high impact of a cancer diagnosis on patients and their families and the increasing costs of cancer treatment call for optimal and efficient oncological care. To improve the quality of care and to minimize...

    Authors: Jolanda C. van Hoeve, Robin W. M. Vernooij, Adegboyega K. Lawal, Michelle Fiander, Peter Nieboer, Sabine Siesling and Thomas Rotter
    Citation: Systematic Reviews 2018 7:49
    Content type: Protocol Published on:
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ISSN: 2046-4053