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Table 5 Methods for formulating conclusions

From: Evaluation of the use of GRADE in dentistry systematic reviews and its impact on conclusions: a protocol for a methodological study

Level of certainty

Conclusion based on a minimally contextualized approach

Conclusion based on a partially contextualized approach

High

Intervention X increases/decreases the outcome by an important/negligible amount when compared to intervention Y.

Intervention X increases/decreases the outcome by a negligible/small/moderate/large amount when compared to intervention Y.

Moderate

Intervention X probably increases/decreases the outcome by an important/negligible amount when compared to intervention Y.

Intervention X probably increases/decreases the outcome by a negligible/small/moderate/large amount when compared to intervention Y.

Low

Intervention X may increase/decrease the outcome by an important/negligible amount when compared to intervention Y.

Intervention X may increase/decrease the outcome by a negligible/small/moderate/large amount when compared to intervention Y.

Very low

Intervention X may increase/decrease the outcome by an important/negligible amount when compared to intervention Y, but the evidence is very uncertain.

Intervention X may increase/decrease the outcome by a negligible/small/moderate/large amount when compared to intervention Y, but the evidence is very uncertain.