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Table 5 Photodynamic therapy

From: Keloid treatments: an evidence-based systematic review of recent advances

First author, year

Study design

Treatment

Duration

N

Outcome(s)

Follow-up time

Adverse events

Comments

Bu et al, 2020 [85]

P (split scar control)

Excision + RT (5 Gy every 5 days) then split scar PDT

PDT Q1 wk for 4 treatments

10

VSS 7.20 vs 6.25 at 20 months (w/o vs w/PDT)

20 months

Pain, hyperpigmentation, blister

 

Basdew et al., 2013 [86]

P, controlled

Excision + RT (9 Gy ×2) vs excision + PDT

Q6hrs vs interstitial PDT at 4 h, 6 h, and 3 days, later subjects received 6 q1wk topical PDT

34 subjects treated for 45 keloids

Observers POSAS 19.1 vs 24.6 (RT vs PDT)

Independent observers POSAS 14.6 vs 18.6 (RT vs PDT)

64 vs 34.4 weeks (RT vs PDT)

Burning with interstitial PDT requiring IV opioids

Topical PDT sessions required oral NSAIDs, morphine, or transdermal fentanyl

 
  1. P prospective trial, RT radiotherapy, Gy gray, PDT photodynamic therapy, qn every n