From: Keloid treatments: an evidence-based systematic review of recent advances
First author, year | Study design | Treatment | Duration | N | Outcome(s) | Follow-up time | Adverse events | Comments |
---|---|---|---|---|---|---|---|---|
Bu et al, 2020 [85] | P (split scar control) | Excision + RT (5 Gy every 5 days) then split scar PDT | PDT Q1 wk for 4 treatments | 10 | VSS 7.20 vs 6.25 at 20 months (w/o vs w/PDT) | 20 months | Pain, hyperpigmentation, blister | |
Basdew et al., 2013 [86] | P, controlled | Excision + RT (9 Gy ×2) vs excision + PDT | Q6hrs vs interstitial PDT at 4 h, 6 h, and 3 days, later subjects received 6 q1wk topical PDT | 34 subjects treated for 45 keloids | Observers POSAS 19.1 vs 24.6 (RT vs PDT) Independent observers POSAS 14.6 vs 18.6 (RT vs PDT) | 64 vs 34.4 weeks (RT vs PDT) | Burning with interstitial PDT requiring IV opioids Topical PDT sessions required oral NSAIDs, morphine, or transdermal fentanyl |