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Table 1 Characteristics of included studies in the systematic review meta-analysis

From: Effect of plasma thrombin-antithrombin complex on ischemic stroke: a systematic review and meta-analysis

Studies

Patients

Country

Confirmed

method

Cases

Average age

Control

Average age

Test time

Test method

From first onset to hospital

Kentaro Takano 1991 [17]

Acute cardioembolic stroke

Japan

2D-echo, CT

22

64.70

25

61.00

< 24 h

ELISA

Within 24 h

Ran Meng 2011 [8]

Cerebral ischemic stroke

China

MRI/DWI/MRA or CTA

152

58.72

46

51.89

< 24 h

ELISA

Within 4.5 h

Fon E A 1994 [24]

Transient ischemic attack (TIA)

Canada

CT

36

68.80

65

65.50

< 7 days, 1 months, 3 months

ELISA

Within 7 days

Ye Naifang 2020 [23]

Acute

ischemic stroke

China

CT and/or MRI

236

70.00

90

69.00

< 12 h

Chemilumi-nescence

Within 24 h

Israel Fernandez Cadenas 2009 [26]

Ischemic stroke

Spanish

CT and MRI

89

72.40

–

–

Admission, 1 h, 2 h,

24 h, 48 h after post-tPA

ELISA

Within 3 h

Haapaniemi E 2004 [27]

Ischemic stroke

Finland

radiologically

55

60.20

55

60.00

2 days, 7 days, 1 months, 3 months

ELISA

Within 24 h

Satoshi Kataoka 2000 [18]

Acute

brain infarction

Japan

CT and MRI

137

68.32

32

66.50

48 h, 1 week,

3 weeks

ELISA

Within 48 h

Yamazaki M 1993 [19]

Cerebral infarction

Japan

CT or MRI

138

65.40

23

60.00

7 days, 1 months,

and in 1 months

EIA

No description

Noriko Ono 1991 [20]

Ischemic stroke

Japan

CT and MRI

98

69.50

50

66.00

< 24 h

ELISA

Within 5 days

Masao Nagayama 1994 [21]

Ischemic stroke

Japan

CT

53

63.50

37

60.00

48 h, 3 days 7 days,

14 days, 1 months

ELISA

Within 3 days

Takano K 1992 [22]

Acute ischemic stroke

Japan

CT and cerebral angiography

54

66.00

20

61.60

48 h, 7 days, 1 mon

ELISA

Within 48 h

David Tanne 2006 [25]

Acute ischemic stroke

USA

CT

361

68

–

–

2 h, 24 h, 7–10 days,

and 3 months

EIA

Within 24 h

  1. CT computed tomography, MRI magnetic resonance imaging, 2D-echo two-dimensional echocardiography, DWI diffusion-weighted imaging, PWI perfusion-weighted imaging, ELISA enzyme-linked immunosorbent assay, EIA enzyme immunoassays