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Table 2 Definitions of levels of evidence for typical risk of broadly defined population used for risk of bias assessment [21, 22]

From: All-cause mortality after major gastrointestinal bleeding among patients receiving direct oral anticoagulants: a protocol for a systematic review and meta-analysis

Quality level

Definition

High

We are very confident that the true prognosis (probability of future events) lies close to that of the estimate

Moderate

We are moderately confident that the true prognosis (probability of future events) is likely to be close to the estimate, but there is a possibility that it is substantially different

Low

Our confidence in the estimate is limited: the true prognosis (probability of future events) may be substantially different from the estimate

Very low

We have very little confidence in the estimate: the true prognosis (probability of future events) is likely to be substantially different from the estimate