PICOS | Searched items |
---|---|
Patients (a + b) | |
 a | The elderly; The old man; The old patient; The elderly patients; The aged |
 b | Intraoperative sedation; Sedation; Surgery sedation, Surgical sedation; Anesthesia and analgesia; Anesthesia sedation; Intraoperative anesthesia; Surgery anesthesia; Surgical anesthesia |
 Interventions | Dexmedetomidine, Dexmedetomidine Hydrochloride, Hydrochloride Dexmedetomidine |
 Comparisons | Midazolam, Benzodiazepine, Compounds, Benzodiazepine, Benzodiazepinones, devazepide |
Outcomes | |
 Primary outcomes | Hemodynamic changes (MAP, HR, SBP, DBP, RR, SPO2), Sedative effect (OAA/S, BIS), and Cognitive function (MMSE, POCD) |
 Secondary outcomes | Analgesic effect (RASS, VAS), Surgical characteristics (operation time, the volume of intraoperative blood loss, time of extubation), Complications or adverse reactions (agitation, hypotension, bradycardia, respiratory depression, postoperative nausea and vomiting, bradycardia and shivering) |
 Studies design | Random control study, Control study, Random control trial, Clinical control trial, Clinical trial, Randomized control trial, Randomized controlled trial |