Table 7 KQ4 eligibility criteria (patient values and preferences of screening)

Population

Individuals (>18 years of age) without a clinical suspicion of prostate cancer and without a history of prostate cancer.

Studies with a mixed population (individuals with prior history of screening and/or prior diagnosis) that do not separate information for our population of interest will be excluded.

Exposure

Experience with outcomes related to screening.

Exposure to clinical scenarios or Information on PSA screening and/or screening attributes (e.g., presented in decision aids).

N/A

Comparator

Depending on the study design, a comparator may be:

• No comparison.

• Different types of clinical scenarios or information on screening.

N/A

Outcomes

Qualitative information about:

• Values and preferences regarding the choice to screen, based on information overall benefits and harms (i.e., the benefit considered worthwhile to undergo burden/harm). Benefits must at least include prostate cancer mortality and/or incidence of cancer risk.

• Intention to undergo screening based on information regarding the patient-important outcomes presented in decision aids.

N/A

Timing

Any timing.

N/A

Setting

Any setting.

N/A

Study design

Any experimental or observational study design (including abstracts if data is available) reporting patient preferences to screen or not to screen (e.g., discrete-choice experiments).

Studies reporting only outcome prioritization, time trade-off, health state values, or willingness to pay.

Systematic reviews^a, cost-effectiveness studies, qualitative studies, case report, and case series.

Analyses of data that were not reported by patients (e.g., databases of health records) or on outcomes outside the perspective of individuals considering prostate cancer screening.

Studies reporting only access to screening; studies on knowledge or awareness about screening.

Language

English or French

N/A

Dates of publication

All dates are included (as per the Vernooij et al. study); however, the current update will include 2017 to present.

N/A