Authors | Year of publication | Only RCTs included | Information sources | No. of studies included | No. of patients | Published protocol | Assessment of benefits | Assessment of adverse effects | GRADE assessment | Assessment of risk of bias | TSA | Conclusion |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Parkinson’s disease | ||||||||||||
Wong et al [18] | 2019 | Yes | PubMed, Web of Science, CENTRAL, clinicaltrials.gov | 5 | 489 | No | Yes | No | No | Only publication bias | No | Deep brain stimulation is effective in tremor suppression regardless of target |
Bratsos et al [19] | 2018 | Yes | EMBASE, MEDLINE, CENTRAL | 8 | 1189 | No | Yes | Yes | No | Yes | No | Deep brain stimulation is effective to improve impairment and quality of life but with a higher risk of serious adverse events |
Mansouri et al [20] | 2018 | Yes | MEDLINE, EMBASE, CENTRAL, ISI Web | 13 | 508 | No | Yes | Yes | Yes | Yes | No | Deep brain stimulation of STN and GPi showed similar effect in reducing motor symptoms |
Xie et al [21] | 2016 | Yes | PubMed, Google scholar, CENTRAL | 16 | 2186 | No | Yes | No | No | Yes | No | Both deep brain stimulation of GPi and STN is effective compared to best medical treatment |
Elgebaly et al [22] | 2018 | No (only RCTs in meta-analysis) | PubMed, CENTRAL, ISI Web | 7 (4 RCTs) | 555 (345 from RCTs) | No | Yes | No | No | Yes | No | Deep brain stimulation of STN and GPi showed equal neuropsychological outcomes |
Essential tremor | ||||||||||||
Lu et al [24] | 2020 | No | PubMed, Embase, Cochrane Library | 46 | 1714 | Registry | Yes | Yes | No | Only publication bias | No | Deep brain stimulation is an effective and safe intervention but with a risk of adverse events |
Altinel [23] | 2019 | Yes | PubMed, EMBASE, CENTRAL | 15 | 1508 | Registry | Yes | No | No | Yes | No | Lesion surgery and deep brain stimulation are equally effective in tremor reduction |
Dystonia | ||||||||||||
Rodrigues et al [25] | 2019 | Yes | CENTRAL, MEDLINE, EMBASE, Web of Science, SciELO, LILACS | 2 | 102 | Yes | Yes | Yes | Yes | Yes | Yes | Deep brain stimulation improves symptoms but there is uncertainty about the improvement of quality of life and safety |
Epilepsy | ||||||||||||
Sprengers et al [26] | 2017 | Yes | CENTRAL, Cochrane Epilepsy Group Specialized Register, PubMed, Clinicaltrials.gov, ICTRP | 12 | 367 | Yes | Yes | Yes | Yes | Yes | No | Deep brain stimulation reduced seizure frequency moderately depending on the placement of electrodes |