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Table 1 Overview of previous reviews of studies of deep brain stimulation for neurological disorders

From: Deep brain stimulation for neurological disorders: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials

Authors

Year of publication

Only RCTs included

Information sources

No. of studies included

No. of patients

Published protocol

Assessment of benefits

Assessment of adverse effects

GRADE assessment

Assessment of risk of bias

TSA

Conclusion

Parkinson’s disease

 Wong et al [18]

2019

Yes

PubMed, Web of Science, CENTRAL, clinicaltrials.gov

5

489

No

Yes

No

No

Only publication bias

No

Deep brain stimulation is effective in tremor suppression regardless of target

 Bratsos et al [19]

2018

Yes

EMBASE, MEDLINE, CENTRAL

8

1189

No

Yes

Yes

No

Yes

No

Deep brain stimulation is effective to improve impairment and quality of life but with a higher risk of serious adverse events

 Mansouri et al [20]

2018

Yes

MEDLINE, EMBASE, CENTRAL, ISI Web

13

508

No

Yes

Yes

Yes

Yes

No

Deep brain stimulation of STN and GPi showed similar effect in reducing motor symptoms

 Xie et al [21]

2016

Yes

PubMed, Google scholar, CENTRAL

16

2186

No

Yes

No

No

Yes

No

Both deep brain stimulation of GPi and STN is effective compared to best medical treatment

 Elgebaly et al [22]

2018

No (only RCTs in meta-analysis)

PubMed, CENTRAL, ISI Web

7 (4 RCTs)

555 (345 from RCTs)

No

Yes

No

No

Yes

No

Deep brain stimulation of STN and GPi showed equal

neuropsychological outcomes

Essential tremor

 Lu et al [24]

2020

No

PubMed, Embase, Cochrane Library

46

1714

Registry

Yes

Yes

No

Only publication bias

No

Deep brain stimulation is an effective and safe intervention but with a risk of adverse events

 Altinel [23]

2019

Yes

PubMed, EMBASE, CENTRAL

15

1508

Registry

Yes

No

No

Yes

No

Lesion surgery and deep brain stimulation are equally effective in tremor reduction

Dystonia

 Rodrigues et al [25]

2019

Yes

CENTRAL, MEDLINE, EMBASE, Web of Science, SciELO, LILACS

2

102

Yes

Yes

Yes

Yes

Yes

Yes

Deep brain stimulation improves symptoms but there is uncertainty about the improvement of quality of life and safety

Epilepsy

 Sprengers et al [26]

2017

Yes

CENTRAL, Cochrane Epilepsy Group Specialized Register, PubMed, Clinicaltrials.gov, ICTRP

12

367

Yes

Yes

Yes

Yes

Yes

No

Deep brain stimulation reduced seizure frequency moderately depending on the placement of electrodes

  1. CENTRAL Cochrane Central Register of Controlled Trials, EMBASE Excerpta Medica Database, GPi globus pallidus internus, GRADE Grading of Recommendations, Assessment, Development and Evaluation, ICTRP International Clinical Trials Registry Platform, ISI Web Web of Science, LILACS Latin American and Caribbean Health Sciences Literature, MEDLINE Medical Literature Analysis and Retrieval System Online, RCT randomised clinical trial, SciELO Scientific Electronic Library Online, STN subthalamic nucleus, TSA trial sequential analysis