Table 3 Sensitivity analysis of P53, MUC1, and HSP60 autoantibodies
Variable | Autoantibody | Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|---|---|
Threshold | Irrespective of the threshold defined (n = 13) | P53 | 0.184 (0.093–0.332) | 0.962 (0.912–0.984) |
Investigator defined-mean + 2SD (n = 6) | 0.227 (0.059–0.580) | 0.954 (0.794–0.991) | ||
Irrespective of the threshold defined (n = 5) | MUC1 | 0.498 (0.209–0.789) | 0.691 (0.257–0.935) | |
Investigator defined-mean + 2SD (n = 4) | 0.548 (0.196–0.858) | 0.615 (0.149–0.936) | ||
Index test | ELISA + immunohistochemistry (n = 4) | HSP60 | 0.558 (0.210–0.857) | 0.802 (0.316–0.973) |
ELISA (n = 3) | 0.197 (0.097–0.358) | 0.979 (0.965–0.988) | ||