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Table 2 Characteristics of selected records

From: The incidence of TB and MDR-TB in pediatrics and therapeutic options: a systematic review

Author, year and reference Research Question(s) or Objective(s) Research Design Study Country (Location) Duration of Study Sample Size (and Study Population) Age of Participants (years) Co-morbidity(ies)
Gledovic et al. 2006 [13] The objective of this study was to establish the tuberculosis incidence and mortality in children in Serbia in the period 1992-2002 Retrospective Serbia 1992 - 2002 135000
Male and Female
0-14 years Missing
Padayatchi et al. 2006 [17] Investigation into Multidrug-Resistant Tuberculous Meningitis in Children in Durban, South Africa Retrospective Durban, South Africa 1992-2003 8
Male and Female
0-11 years HIV
Fairlie et al. 2011 [18] The aim of this study was to review the prevalence and clinical outcome of childhood MDR-TB at two hospitals in Johannesburg, South Africa. Retrospective Gauteng, South Africa 2008 1317
Male and Female
<14 years HIV
Seddon et al. 2012 [9] To describe the clinical presentation, treatment, and outcome for a large cohort of children with confirmed MDR-tuberculosis and evaluate factors influencing treatment response. Retrospective cohort Western Cape , South Africa 1st January 2003 to 31st December 2008 111
Male and Female
Median age= 50 months HIV
Erkens et al. 2014 [19] The objective of the study was to describe the occurrence of TB events among children in the Netherlands Retrospective Netherlands 1993-2012 8357
Male and Female
<14 years Missing
Nabukeera-Barungi et al. 2014 [20] Investigation into the presentation and outcome of tuberculous meningitis among children Retrospective South Africa 1st January 2009 to 31st December 2009 40
Male and Female
Median age=32 months HIV
Ben Ayed et al. 2019 [21] The study aimed to give an update about the epidemiological profile of childhood TB in south of Tunisia and to describe their chronological trends from 1995 to 2016. Retrospective Southern Tunisia 1st January 1995 to 31st December 2016 204
Male and Female
<15 years Missing
Wang et al. 2020 [22] The study aimed to analyse the epidemiological and clinical characteristics, as well as drug resistance in culture-confirmed children with Tuberculosis meningitis (TBM) in Southwest of China. Retrospective Public Health Clinical Center of Chengdu, China January 2013 and December 2018 319
Male and Female
<14 years Missing
Zhou et al. 2020 [23] To evaluate the prevalence of MDR-TB among children age ≤15 years old, from 2008 to 2018. Retrospective Shandong Provincial Chest Hospital, Shandong- China 2008 to 2013 and 2014 to 2018.
10 years
222
Male and Female
Mean age of children was 10.7 ± 4.8 years (range from 3 months to 15 years) Missing