| CMV seropositivity | CMV primary infection | ||||||
---|---|---|---|---|---|---|---|---|
Covariates | Number of studies | Sample size | Proportion % (95 % CI) | I2% (95% CI) | Number of studies | Person-year | Incidence % per year (95% CI) | I2 % (95% CI) |
Overall prevalence | 47 | 29332 | 53.3 (46.5–60.0) | 98 (98–98) | 21 | 3994 | 4.6 (2.6–7.1) | 83 (76–89) |
Groups* | ||||||||
 Childcare workers | 24 | 22194 | 59.3 (49.8–68.6) | 98 (97–98) | 9 | 883 | 7.4 (3.9–11.8) | 89 (81–93) |
 Healthcare workers | 25 | 7138 | 49.5 (40.3–58.7) | 97 (97–98) | 12 | 3111 | 3.1 (1.3–5.6) | 48 (0–73) |
Region | ||||||||
 Africa | 3 | 95 | 47.9 (18.5–78.0) | 96 (91–98) | - |  |  |  |
 North America | 26 | 6781 | 46.6 (37.9–55.5) | 94 (92–95) | 15 | 3272 | 5.9 (3.3–9.0) | 87 (80–91) |
 Asia | 2 | 1242 | 77.9 (49.1–96.8) | 91 (68–97) | 1 | 70 | 2.8 (0.0–8.4) | - |
 Europe | 15 | 20924 | 61.2 (50.2–71.7) | 99 (98–99) | 3 | 352 | 1.1 (0.0–7.4) | 15 (0–91) |
 Oceania | 1 | 290 | 52.1 (46.3–57.8) |  | 2 | 300 | 2.3 (0.0–10.3) | 62 (0–91) |
Diagnostic method | ||||||||
 Anticomplement immunofluorescence | 4 | 1466 | 60.5 (39.4–79.7) | 97 (95–98) | 3 | 1208 | 2.6 (0.1–7.3) | 17 ( 0–91) |
 Complement fixation | 7 | 1636 | 48.6 (31.4–65.9) | 98 (97–99) | 5 | 1178 | 4.4 (1.2–9.2) | 72 (29–89) |
 ELISA | 18 | 5245 | 53.1 (42.7–63.3) | 98 (95–97) | 5 | 1169 | 5.0 (1.8–9.5) | 93 (88–97) |
 Latex agglutination | 6 | 795 | 47.0 (28.9–65.5) | 90 (81–95) | 4 | 258 | 7.9 (2.8–15.1) | 0 (0–85) |
 No specify | 3 | 644 | 24.6 (7.1–48.0) | 98 (97–99) | 1 | 42 | 23.8 (12.0–38.0) | - |
 Other | 7 | 19496 | 66.0 (50.4–80.1) | 95 (92–97) | 2 | 125 | 1.0 (0.0–7.1) | 45 (–) |
 Restriction endonuclease | 2 | 50 | 76.0 (41.3–98.8) | 42 (–) | 1 | 14 | 0.0 (0.0–11.9) | - |
Study design | ||||||||
 Cohort | 25 | 7548 | 52.1 (42.8–61.3) | 97 (97–98) | 21 | 3994 | 4.6 (2.6–7.1) | 83 (76–89) |
 Cross-sectional | 22 | 21784 | 54.7 (44.6–64.6) | 98 (97–98) | - |  |  |  |
Quality | ||||||||
 Good | 19 | 7584 | 58.9 (48.8–68.7) | 98 (97–98) | 10 | 2590 | 5.8 (2.7–9.8) | 88 (79–93) |
 Fair | 13 | 3160 | 51.1 (38.8–63.3) | 96 (95–97) | 8 | 1044 | 3.5 (0.7–7.8) | 67 (30–84) |
 Poor | 15 | 18588 | 46.7 (33.7–59.8) | 98 (97–98) | 3 | 359 | 3.9 (0.1–11.4) | 92 (80–97) |