Patient or population: Pregnant women at any gestational age at high risk of developing hypertensive disorders in pregnancy Settings: Hospital setting Intervention: Antiplatelet agents, anticoagulants, antioxidants, calcium, nitric oxide, and their combinations Comparator: Placebo or no treatment Outcome: Superimposed preeclampsia | ||||||||
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Total studies: 4 RCTs Total participants: 6,342 | Direct estimates RR (95% CI) | Certainty of evidence | Indirect estimates RR (95% CI) | Certainty of evidence | Network estimates RR (95% CI) [95% PrI] | Certainty of evidence | SUCRA | Commentsa |
Antiplatelets (3 RCTs; 6,298 participants) | 0.72 (0.46 to 1.14) | ⊕⊕⊝⊝ Lowb,c | Not estimable | 0.72 (0.46 to 1.14) [0.04 to 14.21] | ⊕⊕⊝⊝ Lowb,c | 69.0% | There was no evidence of inconsistency for global inconsistency test (P = 0.165) | |
Antioxidants (1 RCT; 44 participants) | 0.67 (0.12 to 3.61) | ⊕⊝⊝⊝ Very lowd,e | Not estimable | 0.67 (0.12 to 3.61) [< 0.001 to 37900] | ⊕⊝⊝⊝ Very lowd,e | 60.6% |