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Table 6 Effect of combined SCT on the diabetes parameters (insulin TDD, HbA1c, C-peptide, and adjusted HbA1c) in different follow-up periods

From: Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis

Outcome

Month

Standard mean difference

95% confidence interval

P value

Heterogeneity

Combined SCT effect

Insulin TDD (U/kg/day)

3

− 0.586

− 1.204/− 0.509

0.000

00.0%

6

− 1.067

− 1.443/− 0.690

0.000

00.0%

12

− 1.652

− 2.070/− 1.234

0.000

00.0%

HbA1c (%)

3

− 0.736

− 1.107/− 0.365

0.000

00.0%

6

− 1.027

− 1.401/− 0.653

0.000

00.0%

12

− 1.334

− 1.749/− 0.918

0.000

00.0%

c-Peptide (ng/ml)

3

1.917

− 0.192/3.641

0.029

92.5%

6

3.025

− 0.773/6.822

0.118

96.5%

12

2.544

0.476/4.612

0.016

93.9%

Adjusted HbA1c

3

− 2.041

− 2.648/− 1.434

0.002

38.4%

6

− 2.590

− 3.074/− 2.107

0.000

00.0%

12

− 3.668

− 4.293/− 3.042

0.000

00.0%