Table 3 The effect of SCT on the diabetes parameters (insulin TDD, HbA1c, c-peptide, and adjusted HbA1c) in different follow-up periods
Outcome | month | No. of studies | No. of patients | Standard mean difference | 95% confidence interval | P value | Heterogeneity | |
|---|---|---|---|---|---|---|---|---|
Meta-analysis Step 1 | Insulin TDD (U/kg/day) | 12 | 7 | 171 | − 1.741 | − 3.034/− 0.448 | 0.008 | 94.5% |
HbA1c (%) | 12 | 6 | 153 | − 0.169 | − 0.697/0.358 | 0.530 | 84.6% | |
c-Peptide (ng/ml) | 12 | 7 | 171 | 0.413 | 0.097/0.728 | 0.010 | 54.5% | |
Meta-analysis Step 2 | Insulin TDD (U/kg/day) | 3 | 20 | 381 | − 1.245 | − 1.727/− 0.764 | 0.000 | 88.3% |
6 | 18 | 343 | − 1.483 | − 2.049/− 0.918 | 0.000 | 90.2% | ||
12 | 21 | 436 | − 2.154 | − 2.975/− 1.332 | 0.000 | 95.7% | ||
HbA1c (%) | 3 | 21 | 388 | − 1.283 | − 1.722/− 0.795 | 0.000 | 88.8% | |
6 | 21 | 446 | − 1.624 | − 2.334/− 0.914 | 0.000 | 94.9% | ||
12 | 24 | 598 | − 1.832 | − 2.427/-1.237 | 0.000 | 94.7% | ||
c-Peptide (ng/ml) | 3 | 15 | 305 | 0.369 | 0.135/0.872 | 0.003 | 85.1% | |
6 | 16 | 328 | 0.757 | 0.288/1.226 | 0.002 | 87.0% | ||
12 | 21 | 550 | 1.146 | 0.534/1.759 | 0.000 | 94.7% | ||
Adjusted HbA1c | 3 | 16 | 318 | − 2.406 | − 3.415/− 1.397 | 0.000 | 95.7% | |
6 | 17 | 367 | − 3.883 | − 5.479/− 2.287 | 0.000 | 95.8% | ||
12 | 18 | 432 | − 3.828 | − 5.538/− 2.118 | 0.000 | 98.3% | ||