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Table 2 The number of patients suffering from each side effect in each system organ class according to the CTCAE. Articles reported each side effect was also mentioned in references column. (SOC, system organ class according to CTCAE; Terms, CTCAE terms for each sign or symptom, grading each side effect performed according to the CTCEA scoring chart)

From: Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis

Categories

Disease

Grade 1

Grade 2

Grade 3

Grade 4

Grade 5

Total

References

Blood and lymphatic system disorders

Febrile neutropenia

  

70

  

70

[11, 33, 37, 39, 46, 47]

White blood cell decreased (leukopenia)

10

    

10

[35, 38, 44, 49]

Cardiac disorders

Sinus bradycardia

1

    

1

[35]

Endocrine disorders

Hyperthyroidism (Graves)

 

3

   

3

[35, 39]

Hypothyroidism

 

5

   

5

[35, 37, 39, 42, 49]

Gastrointestinal disorders

Diarrhea

 

15

   

15

[11, 35, 38, 46, 49]

Dyspepsia

 

9

   

9

[11]

Mucositis oral

 

2

1

  

3

[11, 35, 49]

Nausea

3

126

   

129

[11, 33, 35, 37, 39, 42, 44, 46, 47, 49]

Vomiting

3

110

   

113

[33, 35, 37,38,39, 42, 44, 49]

General disorders and administration site conditions

Edema limbs

 

3

   

3

[11, 46]

Fever

60

34

   

94

[11, 33, 35, 42, 44, 46, 47, 49]

Generalized edema (fluid overload)

3

    

3

[35, 49]

Immune system disorders

Allergic reaction

  

2

  

2

[11]

Infections and infestations

Bacteremia

 

5

   

5

[39[71]

Catheter-related infection

 

4

   

4

[35, 49]

Folliculitis

1

    

1

[36]

Herpes simplex reactivation

 

2

   

2

[35, 49]

Lung infection (pneumonia)

  

3

  

3

[35, 49]

Sepsis

   

4

2

6

[11, 47]

Sinusitis

 

2

   

2

[35, 49]

Skin infection (pyoderma)

  

2

  

2

[35, 49]

Vaginal infection (vulvovaginal candidiasis)

 

1

   

1

[52]

Injury, poisoning, and procedural complications

Vascular access complication

 

2

   

2

[11, 47]

Venous injury

 

2

   

2

[35, 49]

Investigations

Activated partial thromboplastin time prolonged (coagulopathy)

 

1

   

1

[11]

Alanine aminotransferase increased

1

    

1

[46]

Bone marrow hypocellular (BM suppression)

 

15

15

5

 

35

[11, 37, 39]

Neutrophil count decreased (neutropenia)

7

    

7

[37, 38]

Weight loss

7

7

   

14

[38]

Metabolism and nutrition disorders

Anorexia

13

    

13

[35, 49]

hypokalemia

 

2

   

2

[35, 49]

Metabolism and nutrition disorders—other, specify (nutrition support)

  

1

  

1

[11]

Musculoskeletal and connective tissue disorders

Rhabdomyolysis

 

2

   

2

[35, 49]

Neoplasms benign, malignant and unspecified (incl. cysts and polyps)

Neoplasms benign

   

1

 

1

[48]

Nervous system disorders

Headache

 

1

   

1

[36]

Renal and urinary disorders

Cystitis non-infective

1

1

   

2

[33]

Dysuria

1

    

1

[35, 49]

hematuria

 

1

   

1

[11]

Reproductive system and breast disorders

Irregular menstruation

 

3

   

3

[39]

Oligospermia

22

    

22

[41]

Reproductive system—other, specify (hypogonadism)

 

2

   

2

[35, 49]

Respiratory, thoracic, and mediastinal disorders

Epistaxis

 

3

   

3

[35, 49]

Pharyngeal mucositis

1

    

1

[35]

Pneumothorax

 

1

   

1

[11]

Skin and subcutaneous tissue disorders

Alopecia

3

128

   

131

[11, 33, 35, 37,38,39, 42, 44]

Purpura (hemorrhagic rash)

  

1

  

1

[47]

Rash maculopapular (skin rash)

20

2

2

  

24

[11, 35, 47]

Urticaria

2

3

   

5

[35, 49]