Categories | Disease | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | Total | References |
---|---|---|---|---|---|---|---|---|
Blood and lymphatic system disorders | Febrile neutropenia | 70 | 70 | |||||
White blood cell decreased (leukopenia) | 10 | 10 | ||||||
Cardiac disorders | Sinus bradycardia | 1 | 1 | [35] | ||||
Endocrine disorders | Hyperthyroidism (Graves) | 3 | 3 | |||||
Hypothyroidism | 5 | 5 | ||||||
Gastrointestinal disorders | Diarrhea | 15 | 15 | |||||
Dyspepsia | 9 | 9 | [11] | |||||
Mucositis oral | 2 | 1 | 3 | |||||
Nausea | 3 | 126 | 129 | |||||
Vomiting | 3 | 110 | 113 | |||||
General disorders and administration site conditions | Edema limbs | 3 | 3 | |||||
Fever | 60 | 34 | 94 | |||||
Generalized edema (fluid overload) | 3 | 3 | ||||||
Immune system disorders | Allergic reaction | 2 | 2 | [11] | ||||
Infections and infestations | Bacteremia | 5 | 5 | [39[71] | ||||
Catheter-related infection | 4 | 4 | ||||||
Folliculitis | 1 | 1 | [36] | |||||
Herpes simplex reactivation | 2 | 2 | ||||||
Lung infection (pneumonia) | 3 | 3 | ||||||
Sepsis | 4 | 2 | 6 | |||||
Sinusitis | 2 | 2 | ||||||
Skin infection (pyoderma) | 2 | 2 | ||||||
Vaginal infection (vulvovaginal candidiasis) | 1 | 1 | [52] | |||||
Injury, poisoning, and procedural complications | Vascular access complication | 2 | 2 | |||||
Venous injury | 2 | 2 | ||||||
Investigations | Activated partial thromboplastin time prolonged (coagulopathy) | 1 | 1 | [11] | ||||
Alanine aminotransferase increased | 1 | 1 | [46] | |||||
Bone marrow hypocellular (BM suppression) | 15 | 15 | 5 | 35 | ||||
Neutrophil count decreased (neutropenia) | 7 | 7 | ||||||
Weight loss | 7 | 7 | 14 | [38] | ||||
Metabolism and nutrition disorders | Anorexia | 13 | 13 | |||||
hypokalemia | 2 | 2 | ||||||
Metabolism and nutrition disorders—other, specify (nutrition support) | 1 | 1 | [11] | |||||
Musculoskeletal and connective tissue disorders | Rhabdomyolysis | 2 | 2 | |||||
Neoplasms benign, malignant and unspecified (incl. cysts and polyps) | Neoplasms benign | 1 | 1 | [48] | ||||
Nervous system disorders | Headache | 1 | 1 | [36] | ||||
Renal and urinary disorders | Cystitis non-infective | 1 | 1 | 2 | [33] | |||
Dysuria | 1 | 1 | ||||||
hematuria | 1 | 1 | [11] | |||||
Reproductive system and breast disorders | Irregular menstruation | 3 | 3 | [39] | ||||
Oligospermia | 22 | 22 | [41] | |||||
Reproductive system—other, specify (hypogonadism) | 2 | 2 | ||||||
Respiratory, thoracic, and mediastinal disorders | Epistaxis | 3 | 3 | |||||
Pharyngeal mucositis | 1 | 1 | [35] | |||||
Pneumothorax | 1 | 1 | [11] | |||||
Skin and subcutaneous tissue disorders | Alopecia | 3 | 128 | 131 | ||||
Purpura (hemorrhagic rash) | 1 | 1 | [47] | |||||
Rash maculopapular (skin rash) | 20 | 2 | 2 | 24 | ||||
Urticaria | 2 | 3 | 5 |