Table 1 Characteristic of 35 eligible papers included in this systematic review
Stem cell type | Author and year | type of study | Sample size | Mean age of patients (years) | Mean history of disease (years) | Mean dose of injected cells/kg | rout of injection | Number of insulin free | Mean follow-up period (months) | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
MSC | Carlsson 2015 | RCT | 18 | 24 | 0.04 | 2.75 × 106 | Peripheral vein | 0 | 12 | [27] |
Esfahani 2015 | N-RCT | 23 | 12.56 | 0.3 | 2 × 106 | Peripheral vein | 2 | 12 | [28] | |
Hu 2013 | RCT | 29 | 17.6 | 0.42 | 2.6 × 107 | Peripheral vein | 3 | 24 | [29] | |
Liu 2013 | Case study | 1 | 26 | 0.08 | 5.2 × 107 | Pancreatic dorsal artery | 0 | 36 | [30] | |
Mesples 2013 | Case study | 3 | 7 | 0.15 | 181 × 106 | Intra-hepatic parenchyma | 0 | 12 | [31] | |
Ulyanova 2019 | Case study | 5 | 30 | Not mentioned | 96 × 106 | Peripheral vein | 0 | 3 | [32] | |
HSC | Cantu-Rodriguez 2016 | N-RCT | 16 | 12 | 0.25 | 11.54 × 106 | Peripheral vein | 7 | 34 | [33] |
Ghodsi 2015 | N-RCT | 16 | 14.9 | 1 | 45 × 106 | Peripheral vein | 3 | 12 | [34] | |
Couri 2009 | N-RCT | 23 | 18.4 | 0.05 | 3.0 × 106 | Peripheral vein | 20 | 29.8 | [35] | |
D’Addio 2014 | N-RCT | 65 | 20.4 | 0.83 | 5.8 × 106 | Peripheral vein | 46 | 48 | [11] | |
Ghodsi 2012 | RCT | 30 | 21.61 | 4.32 | 45 × 106 | Peripheral vein | 0 | 12 | [36] | |
Gu 2012 | N-RCT | 28 | 17.6 | 0.22 | Not mentioned | Peripheral vein | 20 | 23 | [37] | |
Gu 2014 | N-RCT | 42 | 8.04 | 0.25 | Not mentioned | Peripheral vein | 3 | 29 | [38] | |
Gu 2017 | N-RCT | 40 | 17.9 | 0.16 | Not mentioned | Peripheral vein | 14 | 48 | [39] | |
Haller 2011 | N-RCT | 24 | 5.1 | 0.25 | Not mentioned | Peripheral vein | 0 | 24 | [40] | |
Leal 2012 | N-RCT | 13 | 16 | 0.1 | Not mentioned | Peripheral vein | 4 | 24 | [41] | |
Li 2012 | N-RCT | 13 | 14.1 | 0.41 | 2 × 106 | Peripheral vein | 3 | 42.38 | [42] | |
Mesples 2007 | N-RCT | 12 | 36 | 13 | 1 × 106 | Pancreatic circulation | 4 | 6 | [43] | |
Shen 2012 | case study | 1 | 21 | 0 | 5.8 × 106 | Peripheral vein | 1 | 70 | [44] | |
Snarski 2009 | case study | 1 | 28 | 0.07 | 3.03 × 106 | Peripheral vein | 1 | 3 | [45] | |
Snarski 2011 | N-RCT | 8 | 25.8 | 0.16 | 3 × 106 | Peripheral vein | 8 | 7 | [46] | |
Snarski 2016 | N-RCT | 24 | 26.5 | 0.17 | 4.19 × 106 | Peripheral vein | 20 | 52 | [47] | |
Tootee 2015 | N-RCT | 72 | 17.52 | 0.43 | 45 × 106 | Peripheral vein | 0 | 12 | [48] | |
Voltarelli 2007 | N-RCT | 15 | 19.2 | 0.05 | 11.0 × 106 | Peripheral vein | 8 | 18.8 | [49] | |
Xiang 2016 | N-RCT | 112 | 15.58 | 0.1 | 3 × 106 | Peripheral vein | 0 | 15.13 | [50] | |
Ye 2017 | N-RCT | 18 | 18.86 | 0.42 | 2 × 105 | Peripheral vein | 0 | 12 | [51] | |
Zhang 2012 | N-RCT | 9 | 18.5 | 0.16 | 2.63 × 106 | Peripheral vein | 6 | 12 | [52] | |
Combined SC | Cai 2016 | RCT | 63 | 19.33 | 9.24 | 106.78 × 106 HSC 1.1 × 106 MSC | Dorsal pancreatic artery | 0 | 12 | [53] |
Dave 2013 | Case study | 1 | 30 | 15 | 34 × 106 HSC 5.4 × 104 MSC | Portal and thymus circulation | 0 | 13 | [54] | |
Dave 2014 | Case study | 2 | 5,9 | 7,2 | 51.7 × 106 HSC 1.66 × 104 MSC | portal and thymus circulation | 0 | 18,24 | [55] | |
Dave 2015 | N-RCT | 10 | 20.2 | 8.1 | 60.55 × 106 HSC 2.7 × 106 MSC | Portal and thymus circulation | 0 | 31.71 | [56] | |
Thakkar 2015 | N-RCT | 20 | 19.95 | 8 | 2.21 × 104HSC 2.65 × 104 MSC | Portal system and thymus artery | 0 | 54.24 | [57] | |
Trivedi 2008 | N-RCT | 5 | 20.2 | 4.5 | 3.15 × 106 (HSC + MSC) | Portal circulation | 0 | 2.9 | [58] | |
Trivedi 2011 | N-RCT | 2 | 18 | 11 | 3.8 × 106 (HSC + MSC) | Portal circulation | 0 | 27 | [59] | |
Vanikar 2010 | N-RCT | 11 | 21.1 | 8.2 | 26.96 × 108 HSC 11.55 × 107 MSC | Portal circulation | 0 | 7.3 | [60] |