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Table 1 A descriptive summary of the characteristics of the included studies

From: Strategies to overcome vaccine hesitancy: a systematic review

Author

Study type

Name of country

Study setting

Participants

Interventions

Risk of bias score

Oche et al., 2011 [15]

Controlled community trial

Nigeria

Town with the vast majority of the population largely farmers and illiterates

Mothers of children aged 0 to 23 months

Community health training

6/10

Brugha et al., 1996 [16]

Controlled trial

Ghana

Town where regular immunization services were available

Mothers of 12–18-month-old children

Community health training

7/10

Zhang et al., 201 9[36]

Cross-sectional

Australia

Nationally representative sample

Parents with at least one child under 5 years

Media engagement

4/10

Rahman et al., 2013 [17]

Pre-post interventions without control

Iraq

District with both rural and urban population

Villages with a DPT 3 coverage rate < 20% and 15–24 infants below 1 year

Community health training

5/10

Williams et al., 2019 [47]

Cross-sectional

USA

Urban geographic area

Religious organizations with at least one religious leader or equivalent located in Denver county

Community health training

NA

Nasiru et al., 2012 [21]

Pre-post interventions without control

Nigeria

Local council with high reported cases of polio disease and very low vaccination uptake

Children under the age of 5

Community health training

7/10

Ofstead et al., 2013 [22]

Pre-post interventions with control

USA

Manufacturing corporation

Full-time employees and their dependents

Community health training

6/10

Ansari et al., 2007 [29]

Pre-post

India

High risk urban areas

High-risk urban areas

Technology-based health literacy

7/10

Usman et al., 2011 [23]

Randomized controlled trial

Pakistan

Rural EPI centers

All children visiting the selected EPI centers for DTP1

Community health training

9/10

Williams et al., 2013 [18]

Cluster-randomized controlled trial

USA

Private pediatric practices in urban area

Parent with a full-term infant less than 30 days old

Technology-based health literacy

9/10

Maltezou et al., 2009 [30]

Cross-sectional

Greece

Public hospitals

Greek public hospitals

Technology-based health literacy

6/10

Mouzoon, M. et al., 2010 [24]

Retrospective study

USA

A large multispecialty medical organization

Pregnant women and healthcare workers

Incentive based approach

8/10

Fiks, A.G et al., 2013 [31]

Cluster-randomized controlled trial

USA

Urban primary care practices

Girls 11 through 17 years of age due for at least 1 dose of the HPV vaccine

Technology-based health literacy

5/10

Spleen, A.M, et al., 2011 [19]

Pre-post

USA

Rural population with high poverty rates, high unemployment rates, low access to healthcare, and excess cancer burden, including cervical cancer

Parents of daughters age 9–17 years

Community health training

7/10

Muehleisen et al., 2007 [32]

Pre-post with control

Switzerland

Hospital in urban setting

Children aged 61 days to 17 years

Technology-based health literacy

7/10

Banerjee et al., 2010 [25]

Cluster-randomized controlled trial

India

Rural Rajasthan

Children aged 1–3 years

Incentive-based approach

9/10

Barham et al., 2008 [26]

Cluster-randomized controlled trial

The Republic of Nicaragua

Rural

Children 12–23-month-old and above

Incentive-based approach

7/10

Stitzer,M.L, et al. 2009 [27]

Randomized controlled trial

USA

General Hospital

Individual aged 18–64 years

Incentive-based approach

7/10

Robertson et al., 2013 [28]

Cluster-randomized trial

Zimbabwe

Four socioeconomic strata were selected: subsistence farming areas, roadside trading settlements, agricultural estates, and small towns

households with children younger than 18 years

Incentive-based approach

8/10

Stockwell et al., 2012 [37]

Two randomized controlled trials

USA

Urban, low-income population

Parents with children aged 11 to 18 years and families with a child aged 7 to 22 months lacking 1Hib dose

Media engagement

8/10

Milkman et al., 2011 [38]

Randomized controlled trial

USA

A large firm

Employees

Media engagement

8/10

Lemstra,M. et al. 2011 [40]

Cluster-randomized trial

Canada

Low-income setting

Parents of children who were behind in MMR immunizations

Media engagement

8/10

Clark et al., 2015 [41]

Internet-based cross-sectional survey

USA

Nationally representative sample

Parents of children 0 to 17 years of age

Media engagement (preferred mode of communication)

8/10

Kharbanda et al., 2009 [42]

Qualitative evaluation

USA

Three urban community health centers and two private practices in New York City

Parents with at least 1 child aged 10 to 19 years

Media engagement

8/10

Ahlers-Schmidt et al., 2010 [33]

Formative survey

USA

Low-income setting

Parents with children under 6 years of age at a Midwestern Pediatric Residency clinic

Technology-based health literacy

6/10

Hofstetter et al., 2013 [43]

Cross-sectional study

USA

Urban setting

Parents of 6–59-month-old children and providers

Media engagement (preferred recalled reminder mode)

7/10

Lau et al., 2012 [20]

Randomized controlled trial, cross-sectional study

Australia, Nigeria

University urban setting

University students and staff. Mothers and their infants aged 0–3 months

Community health training

9/10

Brown et al., 2017 [44]

Cross-sectional study

Nigeria

Urban and sub-urban community health facility

Mothers of infants

Media engagement (preferred recalled reminder mode)

6/10

Saville et.al, 2014 [45]

Cross-sectional, randomized, controlled trial

USA, Australia

Both urban and rural university

Parents of children 19–35-month-old

University students and staff

Media engagement (preferred recalled reminder mode)

6/10

Cates et al., 2011 [34]

Assessment

4 North Carolina counties

Rural area

Mothers of girls aged 11–12

Media engagement (preferred recalled reminder mode)

6/10

Pandey et al., 2011 [35]

Cross-sectional

India

Medical school

Students of medical school

Technology-based health literacy

6/10

Garcia-Dia, 2017 [46]

Case-control study

Philippines

Rural setting

Parents of the 12–24 months children

Media-based approach

6/10

Moniz et al., 2013 [39]

Randomized controlled trial

USA

Outpatient clinic

Obstetric patients at less than 28 weeks of gestation pending the flu shot

Media-based approach

8/10