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Table 2 The credibility of the evidence in meta-analyses included studies

From: The environmental risk factors prior to conception associated with placental abruption: an umbrella review

Risk factors

Number of cases

Summary associations (p-value) per random-effects calculations

Small-study effects (p-value for Egger)

Excess of significance bias (p-value)

Prediction intervals

Largest study nominally significant (p-value)

Heterogeneity (I2%)

Sensitivity analysis

Classification

Maternal asthma

1451

0.0002

0.931

0.102

1.05–1.62

0.667

44.8

T = 1.212, G = 1.719

Suggestive

Maternal pre-pregnancy BMI

Underweight

Overweight

Obese

773

666

1036

0.0036

0.0007

0.0002

0.844

0.470

0.599

0.252

0.002

0.277

0.51–16.03

0.75–0.93

0.81–0.94

< 0.01

0.007

< 0.01

55.2

0.0

28.2

T = 1.389, G = 2.124

T = 1.389, G = 2.124

T = 1.333, G = 2.001

Weak

Weak

Suggestive

Prior cesarean section

29,001

0.0003

0.140

0.002

0.85–6.50

< 0.0001

0.0

T = 2.160, G = 3.743

Suggestive

Cocaine use

1123

< 0.0001

0.953

0.003

2.39–5.68

0.001

0.0

T = 3.199, G = 5.853

Suggestive

Endometriosis

33,378

0.0001

9.929

0.238

0.94–2.50

< 0.0001

82

T = 1.454, G = 2.266

Suggestive

Fetal sex

21,396

0.7710

0.544

0.741

0.65–1.62

< 0.001

92.9

T = 0.995, G = Nan

NS

Chronic hypertension

1539

< 0.0001

0.046

0.042

1.67–3.40

0.0006

0.0

T = 2.414, G = 4.262

Suggestive

preeclampsia

5622

0.0338

0

0.901

1.04–2.50

0.04

0.0

T = 1.379, G = 2.102

Weak

Uterine leiomyoma

5137

0.0036

0.915

0.602

0.51–16.03

< 0.01

82.6

T = 2.182, G = 3.788

Weak

Marijuana use

488

0.0002

0.940

0.003

1.30– 2.37

0.026

0.0

T = 1.614, G = 2.609

Weak

Advanced maternal age

215,829

< 0.0001

0.035

0.291

1.12–1.51

< 0.0001

88.3

T = 1.608, G = 2.598

Suggestive

Maternal smoking

26,038

< 0.0001

0.477

0.001

1.49–2.32

< 0.01

65.8

T = 1.790, G = 2.980

Suggestive

Use of ART

75,983

0.0009

0.761

0.772

0.70–3.88

< 0.0001

36

T = 1.207, G = 1.708

Suggestive

  1. BMI body mass index, ART assisted reproductive techniques