Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia

Lin, Lin; Li, Pugui; Liu, Xin; Xie, Xiuyuan; Liu, Liping; Singh, Anjani Kumar; Singh, Himanshu Narayan

doi:10.1186/s13643-022-01914-7

Systematic Reviews

Table 1 Characteristic of included studies in a meta-analysis

From: Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia

S. no	Ref. no.	Country	Ethnicity	Total cases	Total control	Genes	Variant studied	Genotype method	Age case [mean ± SD]	Age control [mean ± SD]	HWE	Source of control	NOS quality score
Studies included for the CYP17 gene polymorphism
1.	[2]	Iraq	Caucasian	50	50	CYP17	34 A1/A2	PCR-RFLP	45-80	45–60	YES	HB	5
2.	[5]	India	Asian	100	100	CYP17	34 A1/A2	PCR-RFLP	63.9 ± 8.9	64.1 ± 7.8	YES	NR	6
3.	[16]	Lebanon	Caucasian	68	79	CYP17	34 A1/A2	PCR-RFLP	65.98 ± 9.97	58.33 ± 10.14	YES	Mixed	7
4.	[27]	Japan	Asian	202	131	CYP17	34 A1/A2	PCR	70.5 ± 9.4	75.3 ± 7.3	YES	HB	6
5.	[28]	China	Asian	182	274	CYP17	34 A1/A2	PCR-RFLP	70 [53-94]	NA	YES	PB	7
6.	[29]	Turkey	Caucasian	80	73	CYP17	34 A1/A2	PCR	NA	NA	YES	NR	5
7.	[30]	Turkey	Caucasian	136	102	CYP17	34 A1/A2	PCR-RFLP	67.07 ± 9.0	64.07 ± 7.3	YES	HB	6
8.	[31]	India	Asian	170	170	CYP17	34 A1/A2	PCR	67.22 ± 69.31	64.87 ± 68.68	YES	HB	5
9.	[32]	Italy	Caucasian	588	580	CYP17	34 A1/A2	PCR-RFLP	69 ± 6	66 ±7	YES	HB	7
10.	[33]	India	Asian	50	50	CYP17	34 A1/A2	PCR-RFLP	62.02 ± 9.66	69.20 ± 5.40	YES	HB	5
11.	[34]	China	Asia	452	501	CYP17	34 A1/A2	PCR-RFLP	58.02 ± 7.38	57.28 ± 7.61	YES	HB	7
Studies included for the VDR gene polymorphism
1.	[15]	India	Asian	160	160	VDR	Taq-I,Bsm-I,Fok-I	PCR-RFLP	64.4 ± 9.1	62.9 ± 9.7	YES	HB	6
2.	[16]	Lebanon	Caucasian	68	79	VDR	Taq-I,Bsm-I, Apa-I, Fok-I	PCR-RFLP	65.98 ± 9.97	58.33 ± 10.14	YES	Mixed	7
3.	[17]	China	Asian	200	200	VDR	Fok-I	PCR-RFLP	73.9 ± 2.7	73.56 ± 2.68	YES	HB	5
4.	[34]	China	Asia	452	501	VDR	Apa-I, Fok-I	PCR-RFLP	58.02 ± 7.38	57.28 ± 7.61	YES	HB	7
5.	[35]	Netherland	Caucasian	93	56	VDR	Taq-I	PCR-RFLP	66.4 ± 7.3	64.4 ± 10.6	YES	HB	6
6.	[36]	Japan	Asian	209	128	VDR	Taq-I,Bsm-I, Apa-I	PCR-RFLP	70.4 ± 9.4	73.5 ± 7.1	YES	PB	6
7.	[37]	Japan	Asian	83	90	VDR	Taq-I	PCR-RFLP	71.8 ± 6.0	67.8 ± 7.2	YES	HB	7
8.	[38]	Thailand	Asian	44	30	VDR	Taq-I,Bsm-I, Apa-I	PCR	NA	NA	YES	HB	5
9.	[39]	China	Asian	189	502	VDR	Fok-I	PCR-RFLP	68.6 ± 68.5	71.7 ± 68.7	YES	HB	6
10.	[40]	Brazil	Caucasian	41	169	VDR	Taq-I,Bsm-I, Apa-I, Fok-I	PCR-RFLP	66.2 ± 10.6	23 ± 4.5	YES	HB	8
Studies included for the ACE gene polymorphism
1.	[41]	Lebanon	Caucasian	69	69	ACE	I/D polymorphisms	PCR	69.1 ± 8.4	55.8 ± 11	YES	HB	7
2.	[42]	India	Asian	200	200	ACE	I/D polymorphisms	PCR	58.3 ± 6	57.6 ± 3.4	YES	HB	5
3.	[43]	Iraq	Caucasian	75	81	ACE	I/D polymorphisms	PCR-RFLP	56.4 ± 3.9	49.2 ± 6.1	YES	HB	5
4.	[44]	Mexico	Caucasian	20	38	ACE	I/D polymorphisms	PCR-RFLP	NA	NA	Yes	HB	5

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ISSN: 2046-4053

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