Paediatric tuberculosis diagnosis using Mycobacterium tuberculosis real-time polymerase chain reaction assay: a systematic review and meta-analysis

Table 2 Summary of statistical results for pulmonary tuberculosis (PTB) and extra-pulmonary tuberculosis (EPTB) clinical samples

Test property	Summary of measure test accuracy^a (95%)	Test of heterogeneity
PTB (n = 11; ^b3209) AUC = 0.98		χ2 (d.f. = 10)	l²	p value
Sensitivity	56(51–62)	151.22	93.4	< 0.001
Specificity	97(96–98)	277.67	96.4	< 0.001
Positive likelihood ratio (PLR)	70.73 (8.55–585.40)	205.09	95.1	< 0.001
Negative likelihood ratio (PLR)	0.43 (0.28–0.66)	99.77	90.0	< 0.001
Diagnostic odd ratio (DOR)	193.06 (51.21–727.83)	36.66	72.7	< 0.001
EPTB (n = 10; ^b 2327) AUC=0.99		X² (d.f. = 9)	l²	p value
Sensitivity	87(82–91)	47.45	81.00	< 0.001
Specificity	100(99–100)	19.19	53.10	0.0236
Positive likelihood ratio (PLR)	111.91(53.97–232.04)	11.74	23.40	0.2282
Negative likelihood ratio (PLR)	0.15 (0.07–0.30)	29.44	69.40	0.0005
Diagnostic odd ratio (DOR)	1337.84 (441.92–4050.12)	13.02	30.90	0.1610

^aRandom effects model, χ2 chi-squared, d.f. degree of freedom, I² I-squared. ^b number of specimens, n number of studies, CI confidence interval, AUC area under receiver operating characteristics curve, PTB pulmonary tuberculosis, EPTB extra-pulmonary tuberculosis

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