Skip to main content

Table 1 Characteristics of the included studies

From: Paediatric tuberculosis diagnosis using Mycobacterium tuberculosis real-time polymerase chain reaction assay: a systematic review and meta-analysis

Author year
(n)
Country Study design Total number of samples (N) Reference test:
culture
Index test:
RT-PCR
Target sequence
PTB EPTB
Bates et al. (2013) [36] Zambia-(L) Prospective-descriptive 142   Liquid culture (MGIT) RT-PCR Xpert MTB/RIF rpoB probe
Bates et al. (2013) [36] Zambia-(L) Prospective-descriptive   788 Liquid culture (MGIT) RT-PCR Xpert MTB/RIF rpoB probe
Chipinduro et al. (2017) [37] Zimbabwe-(L) A cross-sectional   222 (stool) LJ RT-PCR Xpert MTB/RIF rpoB probe
El Khechine et al. (2009)
[38]
France-(U) Diagnostic case-control 134 BACTEC 9000 MB
LJ
RT-PCR(MX3000) IS6110 gene
Gous et al. (2015) [39] South Africa-(U) Prospective 345 Liquid culture (MGIT) RT-PCR Xpert MTB/RIF rpoB probe
LaCourse et al. (2014) [40] Malawi-(L) Cross-sectional study 300 Bactec MGIT, BD) RT-PCR Xpert MTB/RIF rpoB probe
Memon et al. (2018) [41] India-(L) Diagnostic accuracy study 100 Bactec MGIT 960 RT-PCR Xpert MTB/RIF rpoB probe
Mesman et al. (2019) [42] Peru-(U) Cohort study   259(stool) BACTEC 9000 MB
LJ
TruTip Mtb DNA IS6110 real-time PCR
Nhu et al. (2013) [43] Vietnam-(L) Prospective   96 MGIT, Becton Dickinson) RT-PCR Xpert MTB/RIF rpoB probe
Nicol et al. (2011) [44] South Africa-(U) Prospective-descriptive 452 Liquid culture RT-PCR Xpert MTB/RIF rpoB probe
Nicol et al. (2013) [45] South Africa-(U) Prospective 115 Bactec MGIT 960 RT-PCR Xpert MTB/RIF rpoB probe
Nicol et al. (2018) [46] South Africa-(U) Cohort study 367 MGIT, Becton Dickinson) RT-PCR Xpert MTB/RIF rpoB probe
Oberhelman et al. (2010) [47] Peru-(U) Prospective case-control study   218 (stool, GA, etc.) LJ culture hemi-nested IS6110 PCR IS6110 PCR
Qing-Qin Yin et al. (2014) [48] China-(U) Prospective 255   Solid (LJ) and Liquid culture (Bactec MGIT 960 RT-PCR Xpert MTB/RIF rpoB probe
Rachow et al. (2012) [49] Tanzania-(L) Prospective cohort study 164 Solid (LJ) and Liquid culture (Bactec MGIT 960 RT-PCR Xpert MTB/RIF rpoB probe
Sekadde et al. (2013) [50] Uganda-(L) Cross-sectional diagnostic study 235 Solid (LJ) and Liquid culture (Bactec MGIT 960 RT-PCR Xpert MTB/RIF rpoB probe
Walters et al. (2017) [51] South Africa-(U) Prospective   379 (stool) BACTEC 9000 MB RT-PCR Xpert MTB/RIF rpoB probe
Wang et al. (2013) [52] China-(U) Retrospective 30 Bact/Alert 3D LightCycler® 480 (Roche)  
Wolf et al. (2008) [53] Peru-(U) Diagnostic accuracy study 16 (6+) (stool)   hemi-nested IS6110 PCR IS6110 PCR
Zar et al. (2012) [54] South Africa-(U) Prospective 535 Liquid culture (MGIT) RT-PCR Xpert MTB/RIF rpoB probe
Zar et al. (2013) [55] South Africa-(U) Prospective study 384 Bactec MGIT 960 RT-PCR Xpert MTB/RIF rpoB probe
  1. Key: LJ Löwenstein-Jensen, Middlebrook 7H9 broth liquid growth medium, Middlebrook 7H11 Solid medium, MGIT mycobacterium growth indicator tube, PTB pulmonary TB, EPTB extra-pulmonary TB, n reference list number, L lower- and middle-income countries, U upper middle-income countries