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Table 1 Meta-regression analysis of the relationship between the hemodynamic parameters and PAH prognostic outcomes

From: The prognostic significance of the alterations of pulmonary hemodynamics in patients with pulmonary arterial hypertension: a meta-regression analysis of randomized controlled trials

Outcomes

Predictors

Coefficient#

P value#

R2 analoga

(Y1) ∆6MWD

(X1) ∆mPAP

−7.1067

< .0001

.7397

(X2) ∆PVR

−0.1046

< .0001

.6442

(X3) ∆RAP

−10.6923

.0093

.1011

(X4) ∆CI

42.4492

< .0001

.4574

(Y2) All adverse events

(X1) ∆mPAP

0.1794

.0048

.9111

(X2) ∆PVR

0.0031

.0015

.8217

(X3) ∆RAP

0.2191

.1109

.5224

(X4) ∆CI

−1.7544

.0004

.7701

(X5) ∆6MWD

−0.0141

.1195

.6511

(Y3) Total mortality

(X1) ∆mPAP

0.1143

.0932

.5498

(X2) ∆PVR

0.0022

.0332

.6116

(X3) ∆RAP

0.2412

.0796

.5567

(X4) ∆CI

−1.2136

.0250

.6055

(X5) ∆6MWD

−0.0080

.2600

.7046

(Y4) Hospitalization for PAH

(X1) ∆mPAP

0.1420

.0519

.2792

(X2) ∆PVR

0.0024

.1174

.5761

(X3) ∆RAP

0.0733

.6571

.0000

(X4) ∆CI

−0.6668

.3520

.0000

(X5) ∆6MWD

−0.0079

.2847

.0704

(Y5) Death due to PAH

(X1) mPAP

0.0548

.6496

.0000

(X2) ∆PVR

0.0020

.4046

.0000

(X3) ∆RAP

−0.0016

.9552

.0000

(X4) ∆CI

−0.7086

.5299

.0000

(X5) ∆6MWD

0.0005

.9688

.0000

  1. #Adjusted for age, sex, and baseline WHO function class
  2. aResults of univariate regression analysis