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Table 1 Summary of eligible studies

From: Efficacy of adipose tissue-derived stem cells in locomotion recovery after spinal cord injury: a systematic review and meta-analysis on animal studies

Author; year Gender; strain; species Sample size
SCI; treated
Model Severity of injury Injury to treatment interval (day) Location of injury Immunosuppressive; antibiotic Transplantation type Number of transplanted cell Follow-up (week)
Abdanipour; 2014 [13] Female; Sprague–Dawley; rat 8; 8 Contusion Moderate 7 Lumbar No; Yes IS/IT 3 × 105 12
Aras; 2016 [14] Female; Wistar; rat 7; 14 Compression Severe 0, 9 Thoracolumbar No; No IS/IT 3 × 105 4
da Silva; 2014 [22] NR; Wistar; rat 12; 12 Compression Moderate 7, 14 Thoracic No; Yes IV 1.2 × 106 13
Kang; 2006 [15] Female; Wistar; rat 3; 3 Hemisection Severe 3 Thoracolumbar No; No IV 2 × 106 4
Menezes; 2014 [23] Female; Sprague–Dawley; rat 9; 9 Compression Moderate 0 Thoracic No; Yes IS/IT NR 8
Min; 2017 [24] Female; Sprague–Dawley; rat 5; 8 Contusion Severe 3, 7, 14 Thoracic No; Yes IS/IT 1 × 106 8
Oh; 2012 [25] Male; Sprague–Dawley; rat 10; 10 Compression Severe 0 Thoracic No; No IS/IT 1 × 105 6
Ohta; 2017 [26] Female; Sprague–Dawley; rat 15; 20 Contusion Moderate 8 Thoracolumbar No; Yes IV 2.5 × 106 7
Ohta; 2018 [27] Female; Sprague–Dawley; rat 8; 10 Contusion Moderate 8 Thoracolumbar No; Yes IV 2.5 × 106 6
Rosado; 2017 [28] Male; Wistar; Rat 50; 50 Compression Moderate 0 Thoracic No; Yes IV 1 × 106 3
Sarveazad; 2014 [30] Male; Wistar; rat 6; 6 Contusion Moderate 7 Thoracic No; Yes IS/IT 1 × 106 8
Sarveazad; 2017 [29] Male; Wistar; rat 6; 6 Contusion Moderate 7 Thoracic No; Yes IS/IT 1 × 106 9
Tang; 2016 [31] Female; Sprague–Dawley; rat 16; 16 Contusion Severe 9 Thoracic No; No IS/IT 1 × 106 8
Wang; 2017 [16] Male; Sprague–Dawley; rat 76; 76 Crush Moderate 0 Thoracic No; Yes IS/IT 1 × 106 4
Zhang; 2009 [32] Male; Sprague–Dawley; rat 12; 12 Contusion Moderate 7 Thoracic No; No IS/IT NR 11
Zhang; 2014 [33] Male; Sprague–Dawley; rat 15; 15 Crush Moderate 0 Thoracolumbar Yes; Yes IS/IT 2 × 105 3
Zheng; 2017 [34] Female; Sprague–Dawley; rat 12; 12 Hemisection Severe 0 Thoracolumbar No; No IS/IT 1 × 106 7
Zhou; 2013 [35] Female; Sprague–Dawley; rat 5; 5 Hemisection Severe 0 Thoracic Yes; No IS/IT 2 × 105 4
  1. IS Intraspinal, IT Intrathecal, IV Intravenous, NR Not reported