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Table 2 Characteristics of the included studies on OSA and coronary plaque

From: Obstructive sleep apnea increases the risk of cardiovascular damage: a systematic review and meta-analysis of imaging studies

First author year Country Simple size Subgroup Diagnosis criteria Age, years Male (%) BMI, kg/m2 Hypertension, % Hyperlipidemia, % Diabetes, % ESS AHI, events/h OSA diagnosis methods NOS
Turmel [23] 2009 Canada 19 Low AHI (7) AHI < 15 57 ± 4 6 (86) 28.3 ± 2.9 NA NA NA 9.4 ± 3.7 11.9 ± 1.5 PSG 6
High AHI (12) AHI ≥ 15 63 ± 9 12 (100) 29.9 ± 5.7 NA NA NA 7.8 ± 6.7 39.4 ± 23.3
Sharma [26] 2012 USA 81 Non OSA (32) AHI < 10 54.1 ± 12.7 14 (43) 34.4 24 (77) 13 (42) 8 (26) NA 7.5 PSG 5
OSA (49) AHI ≥ 10 59.6 ± 11.8 31 (63) 34.4 38 (84) 28 (62) 14 (31) NA 42.2
Kent [28] 2013 Ireland 29 Low AHI (15) AHI < 15.5 45.1 ± 8.6 15 (100) 32.2 ± 4.1 0 (0) 0 (0) 0 (0) 7.7 ± 4.8 5.5 ± 5.5 Attended cardiorespiratory polygraphy 6
High AHI (14) AHI ≥ 15.5 44.6 ± 6.4 14 (100) 33.3 ± 5.6 0 (0) 0 (0) 0 (0) 13.2 ± 5.1 45.8 ± 20.1
Tan [24] 2014 Singapore 93 No to mild OSA (61) AHI ≤ 15 52.8 ± 9.0 55 (90.2) 24.9 ± 3.9 25 (41.0) 46 (75.4) 13 (21.3) 7.6 ± 4.5 NA Portable diagnostic device 6
Mod to severe OSA (32) AHI > 15 57.5 ± 6.9 26 (81.2) 26.8 ± 4.2 23 (71.9) 29 (90.6) 11 (34.4) 9.4 ± 3.6 NA
Hamaoka [8] 2018 Japan 32 Mild-moderate OSA (15) AHI 5–29 61.3 ± 12.4 11 (73.3) 26.3 ± 5.0 5 (30) 3 (20) 2 (13.3) NA 20.7 ± 8.4 Full PSG 5
Severe OSA (17) AHI ≥ 30 65.0 ± 9.2 15 (88.2) 26.2 ± 5.3 9 (52.9) 5 (29.4) 4 (23.5) NA 45.2 ± 11.9
Wada [25] 2018 Japan 289 No SDB (201) 3% ODI < 15 66.7 ± 11.3 161 (80.1) 24.2 ± 3.6 147 (73.1) 150 (74.6) 75 (37.3) NA / Nocturnal pulse oximetry 6
SDB (88) 3% ODI ≥ 15 69.1 ± 11.3 81 (92.1) 26.1 ± 4.6 72 (81.8) 73 (83.0) 39 (44.8) NA /
Konishi [9] 2019 Japan 50 Non OSA (35) AHI < 15 69.7 ± 8.9 27 (77) 23.6 ± 3.2 23 (66) 29 (83) 11 (31) NA 7.2 ± 3.8 Standardized PSG 6
OSA (15) AHI ≥ 15 71.8 ± 10.4 10 (67) 23.6 ± 3.3 12 (80) 12 (80) 4 (27) NA 30.9 ± 12.6
Mo [29] 2019 Australia 119 Non-severe OSA (77) AHI < 30 60 ± 11.4 52 (68) 31.7 ± 7 46 (59.7) 41 (53.2) 16 (20.8) NA 29.5 ± 26.9 Laboratory PSG 6
Severe OSA (42) AHI ≥ 30 58.5 ± 11 30 (71) 32.8 ± 11.6 23 (54.8) 20 (47.6) 10 (23.8) NA
Umut [27] 2019 Turkey 214 Non-OSA (43) Not mentioned 52.3 ± 6.4 33 (76.7) 31.2 ± 3.9 13 (30.2) 21 (48.8) 7 (16.3) NA 4.0 ± 2.9 Attended PSG 8
Mild OSA (51) 53.9 ± 6.7 34 (66.7) 32.6 ± 4.2 15 (29.4) 33 (64.7) 6 (11.8) NA 9.8 ± 5.2
Moderate OSA (40) 55.2 ± 5.9 26 (65.0) 34.5 ± 6.9 15 (37.5) 26 (65.0) 9 (22.5) NA 21.8 ± 4.1
Severe OSA (80) 54.9 ± 7.2 62 (77.5) 35.3 ± 5.6 30 (37.5) 42 (52.5) 19 (23.8) NA 43.5 ± 12.9
  1. AHI apnea hypopnea index, BMI body mass index, NOS Newcastle–Ottawa scale, ODI Oxygen Desaturation Index, OSA obstructive sleep apnea, PSG polysomnography, SDB sleep-disordered breathing