Table 4 Risk-of-bias (RoB) levels based on proportion of studies, their sample size, and effective sample size in Mattioni 2020
QUADAS2 tool domain | RoB based on number of studies | RoB based on sample size | RoB based on effective sample size | ||||||
|---|---|---|---|---|---|---|---|---|---|
Risk of bias | Low | Unclear | High | Low | Unclear | High | Low | Unclear | High |
Patient selection | 33% | 33% | 33% | 52% | 26% | 22% | 56% | 18% | 25% |
Index test | 44% | 44% | 11% | 60% | 35% | 5% | 64% | 31% | 5% |
Reference standard | 67% | 33% | 0% | 72% | 28% | 0% | 76% | 24% | 0% |
Flow and timing | 89% | 11% | 0% | 95% | 5% | 0% | 95% | 5% | 0% |