From: Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol
Domains | Description |
---|---|
Age | All same age vs different ages |
Sex | All male vs all female vs mixed |
Comorbidities | All healthy vs models with comorbidities vs mixed |
Breeding | Inbred only vs outbred (wild-type) only vs mixed |
Number of participating centers | Single vs multicentered |
Species | Rats, mice, monkeys, cats, dogs, and others |
TBI models | Fluid percussion injury (FPI), controlled cortical impact (CCI), weight-drop model, acceleration model |
Acute stroke models | Spontaneous vs induced, global vs focal ischemia, endovascular vs open surgery with ligature, embolic, and photothrombosis |
ICH models | Blood vs collagenase injection in cerebral parenchyma |
SAH models | Endovascular perforation of internal carotid artery, blood injection in basal cisterns |
Blood transfusion type | Whole blood vs packed red blood cells |
Anemia | Hemorrhage or hemodilution as part of model preparation |
Co-interventions | Crystalloids, colloids, medications, mechanical ventilation, and others |
Timing of treatment | Immediate vs delayed treatment measures after brain injury |
Death | Animals found dead or sacrificed when met criteria for important deterioration (imminent death) |