Table 1 Structured question

Population

Animal models of:

- Traumatic brain injury

- Ischemic stroke

- Hemorrhagic stroke

(ICH, SAH)

Intervention

Red blood cell transfusion

Comparator

An alternative red blood cell transfusion strategy (hemoglobin threshold/target) or

No transfusion or

Any other intervention

Primary outcomes

Neurobehavioral

Secondary outcomes

All-cause mortality

Infarct size

Intracranial pressure

Cerebral perfusion pressure (CPP)

Cerebral blood flow (CBF)

Brain tissue oxygen tension (PbtO₂)

Study design

Comparative preclinical studies