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Table 2 AGREE II standardized domain scores for childhood SSNS CPGs

From: AGREEing on clinical practice guidelines for idiopathic steroid-sensitive nephrotic syndrome in children

CPGs/AGREE II domain-standardized scores (%) AAP 2009 [25] JSPN 2014 [26,27,28] KDIGO 2012 [29]
Domain 1. Scope and Purpose
Items 1–3: Objectives; Health question(s); Population (patients, public, etc.)
75% 65% 100%
Domain 2. Stakeholder Involvement
Items 4–6: Group Membership; Target population preferences and views; Target users
60% 86% 64%
Domain 3. Rigor of development
Items 7–14: Search methods; Evidence selection criteria; Strengths and limitations of the evidence; Formulation of recommendations; Consideration of benefits and harms; Link between recommendations and evidence; External review; Updating procedure.
41% 74% 84%
Domain 4. Clarity and presentation
Items 15–17: Specific and unambiguous recommendations; Management options; Identifiable key recommendations
78% 90% 100%
Domain 5. Applicability
Items 18–21: Facilitators and barriers to application; Implementation advice/ tools; Resource implications; Monitoring/auditing criteria
19% 16% 22%
Domain 6. Editorial independence
Items 22, 23: Funding body; Competing interests
88% 65% 94%
Overall Assessment 1
(Overall quality)
58% 71% 75%
Overall Assessment 2
(Recommend the CPG for use by four appraisers)
Yes (n = 0);
Yes with modifications (n = 3);
No (n = 1).
Yes (n = 1);
Yes with modifications (n = 3);
No (n = 0).
Yes (n = 2);
Yes with modifications (n = 2);
No (n = 0).
  1. AGREE Appraisal of Guidelines for REsearch & Evaluation, AAP American Academy of Pediatrics, CPGs Clinical Practice Guidelines, JSPN Japanese Society of Pediatric Nephrology, KDIGO Kidney Disease: Improving Global Outcomes, SSNS steroid-sensitive nephrotic syndrome