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Table 2 AGREE II standardized domain scores for childhood SSNS CPGs

From: AGREEing on clinical practice guidelines for idiopathic steroid-sensitive nephrotic syndrome in children

CPGs/AGREE II domain-standardized scores (%)

AAP 2009 [25]

JSPN 2014 [26,27,28]

KDIGO 2012 [29]

Domain 1. Scope and Purpose

Items 1–3: Objectives; Health question(s); Population (patients, public, etc.)

75%

65%

100%

Domain 2. Stakeholder Involvement

Items 4–6: Group Membership; Target population preferences and views; Target users

60%

86%

64%

Domain 3. Rigor of development

Items 7–14: Search methods; Evidence selection criteria; Strengths and limitations of the evidence; Formulation of recommendations; Consideration of benefits and harms; Link between recommendations and evidence; External review; Updating procedure.

41%

74%

84%

Domain 4. Clarity and presentation

Items 15–17: Specific and unambiguous recommendations; Management options; Identifiable key recommendations

78%

90%

100%

Domain 5. Applicability

Items 18–21: Facilitators and barriers to application; Implementation advice/ tools; Resource implications; Monitoring/auditing criteria

19%

16%

22%

Domain 6. Editorial independence

Items 22, 23: Funding body; Competing interests

88%

65%

94%

Overall Assessment 1

(Overall quality)

58%

71%

75%

Overall Assessment 2

(Recommend the CPG for use by four appraisers)

Yes (n = 0);

Yes with modifications (n = 3);

No (n = 1).

Yes (n = 1);

Yes with modifications (n = 3);

No (n = 0).

Yes (n = 2);

Yes with modifications (n = 2);

No (n = 0).

  1. AGREE Appraisal of Guidelines for REsearch & Evaluation, AAP American Academy of Pediatrics, CPGs Clinical Practice Guidelines, JSPN Japanese Society of Pediatric Nephrology, KDIGO Kidney Disease: Improving Global Outcomes, SSNS steroid-sensitive nephrotic syndrome