First author | Title | Study design | Intervention/comparison | Primary (and neurological) outcome(s) | No. of trials | No. of participant | Published/registered protocol | Adverse events | Risk of bias | Conclusion |
---|---|---|---|---|---|---|---|---|---|---|
Serraino et al. [38] | Effects of cerebral near-infrared spectroscopy on the outcome of patients undergoing cardiac surgery | Systematic review and meta-analysis | Cerebral NIRS monitoring compared with no cerebral NIRS monitoring or an alternative goal-directed therapy | Mortality, acute brain injury (stroke or TCI), neurocognitive function, S100B levels | 10 | 1466 (adults) | Yes | No | Yes | Existing evidence shows no effect of the intervention on clinical outcomes. More RCTs at low risk of bias are needed. |
Yu et al. [39] | Cerebral near-infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation | Cochrane review | Cerebral NIRS monitoring compared with blinded or no cerebral NIRS monitoring for perioperative monitoring of brain oxygenation in children and adults | Mortality, postop. stroke/adverse neurodev. outcomes, POD/POCD | 15 | 1822 (adults) | Yes | Yes | Yes | The effect of the intervention is uncertain due to low quality of evidence. More RCTs are needed, especially in the paediatric population, since no such trials exist outside the neonatal care. |
Hyttel-Sørensen et al. [55] | Cerebral near-infrared spectroscopy monitoring for prevention of brain injury in very preterm infants | Cochrane review | Cerebral NIRS monitoring compared with blinded or no cerebral monitoring for at least 24 h in very preterm infants | Mortality, neurodev. disability, IVH, cPVL | 1 | 166 (preterm infants) | Yes | Yes | Yes | Based on one trial with a surrogate primary outcome, the systematic review did not reach sufficient power to prove or disprove the interventions effect on clinical outcomes. More RCTs are needed. |