Table 1 Attributes and levels for scenario 1

Database searches

Number of databases

Medline or another database

Medline + 1 further database

Medline + 2 further databases

Number of reviewers for screening

1 reviewer

2 reviewers, no seeking for consensus

2 reviewers and seeking for consensus

Publication period to be considered

Last 2 years

Last 5 years

Last 10 years

Data extraction

Number of reviewers for data extraction

1 reviewer, no quality assurance

2 reviewers, no quality assurance

2 reviewers and quality assurance

Full-text analysis

No full-text analysis

Full-text analysis for easily obtainable literature only

Full-text analysis

Extent

Type of HTA-domains

Safety, efficacy

Safety, efficacy, economic aspects

Safety, efficacy, economic, and further aspects