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Table 1 Summary of the included studies investigating the accuracy of hypoglycaemia detection of MID and NID

From: Non-invasive and minimally invasive glucose monitoring devices: a systematic review and meta-analysis on diagnostic accuracy of hypoglycaemia detection

Device Author, year Country Technique Number of participants/paired measurements Reference test Type of diabetes Setting Threshold (mg/dl) Mean age (years)/inclusion of children
Eversense (Senseonics) Christiansen, 2018 [19] USA MID 74/16653 Venous blood T1DM: 67.8%
T2DM: 29%
Hospital 70 45.1/no
G4 Platinum (Dexcom) Steineck, 2019 [20] Denmark MID 14/681 (venous) Capillary and venous blood T1DM: 100% Hospital 70 48/no
G4 Platinum, regular algorithm (Dexcom) Laffel, 2016
Study 1 [21]
USA MID 176/2922 Venous and capillary blood T1DM: 99%
T2DM: 1%
Hospital 80 11.4/yes
G4 Platinum, Software 505 algorithm (Dexcom) Laffel, 2016
Study 2 [21]
USA MID 79/2262 Venous and capillary blood T1DM: 100% Home 80 12.2/yes
G4 Platinum (Dexcom) Bailey, 2015 [22] USA MID 51/2236 Venous and capillary blood T1DM: 86%
T2DM: 14%
Hospital and home 70 46.7/no
G4 Platinum (Dexcom) Nakamura, 2015 [23] USA MID 68/9152 (venous) Venous and capillary blood T1DM: 83%
T2DM: 17%
Home and hospital 100, 90, 80, 70 42.2/no
Guardian (Medtronic) Bay, 2013 [24] Denmark MID 72/1786 Venous blood T1DM: 100% Hospital 72, 54, 40 no/55
Guardian (Medtronic) Zijlstra, 2013 [25] Germany MID 18/2317 Capillary blood T1DM: 100% Hospital 70 43/no
Guardian (Medtronic) Bode, 2004 [26] USA MID 68/4435 Capillary blood T1DM: 100% Home 70 44/no
CGMS Gold (Medtronic) Lee, 2012 [27] South Korea MID 12/122 Capillary blood DM: 41.67%
Percentage of T1DM and T2DM not given
Hospital 70 50.6/no
CGMS Gold (Medtronic) Adolfsson, 2009 [28] Sweden MID 12/182 Capillary blood T1DM: 100% During dive 70 31/no
CGMS (Medtronic) Guerci, 2003 [29] France MID 18/ng Capillary blood T1DM: 100% Hospital 55 40.4/no
STS (Dexcom) Rabiee, 2009 [30] USA MID 19/1065 (capillary) Capillary and venous blood DM: 64.21%
hereof 100% T2DM
Hospital 55 61.6/no
GlucoWatch (Cygnus) Hathout, 2005 [31] USA NID 30/327 Capillary blood T1DM: 100% Home 100, 90, 80, 70 9.96/yes
Teledyne Sleep Sentry (Teledyne Avionics) Johansen, 1986 [32] Denmark NID 22/99 Capillary blood DM: 100%
Percentage of T1DM and T2DM not given
Hospital 54 37/no
  1. Laffel 2016, study 1, corresponds to the trial investigating the accuracy of the CGM G4 Platinum with its regular algorithm, whereas Laffel 2016, study 2, corresponds to the trial investigating the accuracy of G4 Platinum with a modified (Software 505) algorithm. ng not given