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Table 1 PICOS criteria for inclusion and exclusion of criteria

From: Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review

Parameter Inclusion criteria Exclusion criteria
Population Adult tube-fed critically ill patients Partial EN
Intervention Supplementation with pre, pro, or synbiotics  
Comparison Placebo or nothing  
Outcome Enteral feed volume, Time to reach full enteral nutrition, the prevalence of feed intolerance and related GI complications (diarrhea, distention, high residual volume)  
Study design Randomized controlled trials In vitro studies
  1. EN Enteral nutrition; GI Gastrointestinal