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Table 1 Summary characteristics of included studies

From: Role of preoperative intravenous iron therapy to correct anemia before major surgery: a systematic review and meta-analysis

Study and the publication year Country Surgery type Mean age (SD): intravenous iron/control or oral iron Patients’ #: intravenous iron/control or oral iron Anemic patients were recruited Comparator Intravenous iron dosage regimen Last follow-up time
Bernabeu-Wittel et al., 2016 [37] Spain Hip fracture surgery 84.6 ± 6.2/82.3 ± 6.9 103/100 Yes Placebo 1000 mg of IV Ferric carboxymaltose (two 500 mg vials diluted in a bottle of 250 mL of saline after randomization and always previously to surgery. 60 days post-hospital discharge
Edwards et al. 2009 [42] UK Colorectal cancer resection 67/70 (median) 34/26 Some patients were anemic Placebo 300 mg iron sucrose in 2 infusions separated at least 24 h apart, 14 days pre-surgery. Hospital discharge
Froessler et al. 2016 [44] Australia Major abdominal surgery 64 ± 15/68 ± 15 40/32 Yes Usual care Ferric carboxymaltose, 15 mg/kg with maximum dose of 1000 mg between 4 and 21 days before surgery. Post-surgery, within 2 days of surgery, participants received 0.5 mg of ferric carboxymaltose per recorded 1 mL of blood loss, if blood loss was > 100 ml. 4 weeks post- surgery.
Garrido-Martín et al. 2012 [38] Spain Cardiac surgery 65 ± 11/65 ± 12 54/52 No Placebo Three doses of iron sucrose 100 mg/24 h during pre- and postoperative hospitalization. 1 month post-discharge
Johansson et al. 2015 [39] Denmark Cardiac surgery 65 ± 8/65 ± 11 30/30 No Placebo A single-dose infusion of 1000 mg with a maximum single dose of 20 mg/kg. The injection was a day before surgery or same day. 4 weeks after surgery
Keeler et al. 2017 [43] UK Colorectal cancer resection Median (IQR) 73·8 (67·4–78·6)/74·7 (67·9–80·8) 55/61 Yes Oral iron Ferric carboxymaltose with a maximum dose of 1000 mg per week and a maximum of 2000 mg during the trial. The first dose of injection was at least 2 weeks pre-surgery. 2–3 months post-hospital discharge
Kim et al. 2009 [40] South Korea Gynecologic surgery for menorrhagia 42.0 ± 7.4/42.3 ± 8.0 30/26 Yes Oral iron A 200-mg dose of intravenous iron sucrose three times a week starting 3 weeks prior surgery until target hemoglobin of 10 g/dL was achieved. The treatment started 3 weeks pre-surgery. Hospital discharge
Serrano-Trenas et al. 2011 [36] Spain Hip fracture surgery in elderly patients 83.46 ± 7.1/82.53 ± 6 .4 99/97 Some patients were anemic Standard protocolized treatment Iron sucrose 200 mg at 48-hour intervals for 3 doses, starting on the day of admission; the first dose was given pre-surgery. The following doses were administered before or after surgery, depending on the time of surgery. 7 days post-surgery
Shah et al. 2016 [41] India Gynecologic surgery for menorrhagia Most of ages are between 40 and 49 years 55/55 Yes Oral iron A 100-mg dose of iron sucrose in 100 ml (2 ampoules) by slow IV infusion. Starting 4-weeks pre-surgery, the dose was repeated on alternate day basis until target hemoglobin of 10 g/dL was achieved. Hospital discharge
Weisbach et al. 1999 [45] Germany Orthopedic or cardio-vascular surgery 64.4 ± 14.7/64.1 ± 9.5 30/30 No Usual care A 200-mg dose of iron sucrose, given after each donation and at the enrolment before the first donation. Hospital discharge