Table 2 Search strategy. An example of the comprehensive literature search performed across the electronic databases, with search terms and limitations applied. Shown search strategy example is from MEDLINE

1

Respiratory Syncytial Virus Infections/

6766

2

"RSV infection".mp. [mp = title, abstract, original title, name of substance word, subject heading word, floating sub-heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms]

3688

3

Asthma/

123943

4

"asthma development".mp. [mp = title, abstract, original title, name of substance word, subject heading word, floating sub-heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms]

748

5

wheeze.mp. [mp = title, abstract, original title, name of substance word, subject heading word, floating sub-heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms]

13574

6

Respiratory Hypersensitivity/

9559

7

atopy.mp. [mp = title, abstract, original title, name of substance word, subject heading word, floating sub-heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms]

10555

8

1 or 2

7938

9

3 or 4 or 5 or 6 or 7

144279

10

8 and 9

948

11

limit 10 to english language

879

12

limit 11 to "all child (0 to 18 years)"

600

13

limit 12 to journal article

558

14

(later or subsequent).mp. [mp = title, abstract, original title, name of substance word, subject heading word, floating sub-heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms]

1217789

15

risk factors/

811027

16

"clinical factor".mp. [mp = title, abstract, original title, name of substance word, subject heading word, floating sub-heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms]

16674

17

14 or 15 or 16

1992676

18

13 and 17

255

19

prophylaxis.mp.

106030

20

Primary Prevention/

18238

21

monoclonal antibody.mp. or Antibodies, Monoclonal/

235160

22

palivizumab.mp. or Palivizumab/

1066

23

motavizumab.mp.

59

24

prevention.mp.

1619597

25

19 or 20 or 24

1664918

26

21 or 22 or 23

235631

27

25 and 26

12613

28

18 and 27

31