First author (year) | Specimen type (no. of specimens CRC/C) | Definition of specimen positive to F. nucleatum | Prevalence of F. nucleatum (+) | OR [95% CI] | Adjusted OR [95% CI] | ||
---|---|---|---|---|---|---|---|
C (%) | CRC (%) | p | |||||
Amitay (2017) [40] | Feces (46/231) | F. nucleatum is detected | 20 | 51 | < 0.001 | 4.16 [2.15–8.07] | --- |
Fukugaiti (2015) [44] | Feces (7/10) | F. nucleatum is detected | 90 | 100 | --- | 2.37 [0.08–66.88] | --- |
Liang (2017) [49] Coh I | Feces (170/200) | F. nucleatum is detected | 72 | 98.2 | < 0.0001 | 21.22 [6.57–68.5] | --- |
Mira-Pascual (2015) [50] | Feces (7/9) | F. nucleatum is detected | 22.2 | 85 | --- | 19.86 [1.47–268.17] | --- |
Biopsy (7/5) | F. nucleatum is detected | 0 | 26,6 | --- | 4.6 [0.18–121.18] | --- | |
Vogtmann (2016) [53] | Feces (52/52) | F. nucleatum is detected | 26.9 | 63.5 | 0.0002 | 4.72 [2.05–10.85] | --- |
Wang (2016) [54] | Feces (10/10) | F. nucleatum is detected | 10 | 60 | --- | 13.5 [1.2–152.21] | --- |
Wu (2013) [57] | Feces (19/20) | F. nucleatum is detected | 0 | 68.4 | --- | 85.15 [4.42–1638.85] | --- |
Yu (2017) [60] | Feces (74/54) | F. nucleatum is detected | 3.7 | 52.7 | 7.53E-08 | 29 [6.57–128] | --- |
Kashani (2020) [63] | Biopsy (35/45) | F. nucleatum is detected | 24 | 68 | 0.0001 | 6.74 [2.5–18.07] | --- |
Repass (2018) [51] | Biopsy (40/40) | The product is amplified in the qPCR reaction | 5 | 40 | --- | 12.67 [2.67–60.05] | --- |
Yu (2016) [59] | Biopsy (93/20) | Average number of bacteria per field ≥ 5, visualized by FISH technique | Invasive 20, in biofilms 10 | Invasive 65.9a, in biofilms 48.4a | < 0.05 | 7.73 [2.38–25.07] e | --- |
Tunsjo (2019) [61] | Feces (23/22) | F. nucleatum detected with ΔCq values < 12 | 0 | 35 | --- | 24.9 [1.33–463.72] | --- |
Biopsy (21/11) | F. nucleatum is detected | 18 | 52 | --- | 4.93 [0.85–28.67] | --- | |
Suehiro (2017) [45] | Feces (158/60) | F. nucleatum detected at a higher level based on cutoff value (> 260 copies )b | 10 | 54 | --- | 10.57 [4.3–25.98] | --- |
Eklof (2017) [47] | Feces (39/65) | F. nucleatum detected at a higher level based on cutoff value (2−ΔCq > 0.00026c≈2−12 )c | 24.3 | 69.2 | --- | 7 [2.89–16.96] | --- |
Xie (2017) [58] | Feces (327/242) | F. nucleatum detected at a higher level based on cutoff value (value is not reported) d | --- | --- | --- | 4.31 [2.96–6.28] | 4.28 f [2.27–8.09] |