Screening for sickle cell disease in newborns: a systematic review

Table 1 Certainty of conclusions regularly inferred for different evidence situations if studies with the same qualitative certainty of results are available according to IQWiG methods

		Number of studies
		1 (with statistically significant effect)	≥ 2
			Homogenous	Heterogeneous
			Meta-analysis statistically significant	Effects in the same direction^a
			Meta-analysis statistically significant	Clear	Moderate	No
Qualitative certainty of results	High	Indication	Proof	Proof	Indication	-
	Moderate	Hint	Indication	Indication	Hint	-
	Low	-	Hint	Hint	-	-

^aEffects in the same direction are present if a clear or moderate direction is recognizable despite of heterogeneity

ISSN: 2046-4053