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Table 1 Search strategy

From: GWAS-identified genetic variants associated with medication-assisted treatment outcomes in patients with opioid use disorder: a systematic review and meta-analysis protocol

Medline (Ovid):
 1. Genome-Wide Association Study/
 2. Genotyping Techniques/
 3. Genome, Human/
 4. Genetic Variation/
 5. genetics/or exp human genetics/
 6. (human* adj2 (genotyp* or genome* or genetic*)).ti,ab,kw,kf.
 7. (GWS or GWAS or GWA).mp.
 8. genome wide.ti,ab,kw,kf.
 9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8
 10. exp Opioid-Related Disorders/
 11. ((opiate* or opioid* or heroin* or codeine* or dilaudid* or fentanyl* or narcotic* or drug* or substance*) adj2 (overdose* or use* or using or misuse* or abus* or dependence* or addict*)).ti,ab,kw,kf.
 12. Opiate Substitution Treatment/
 13. ((opiate* or opioid*) adj2 (treatment* or therap*)).ti,ab,kw,kf.
 14. exp buprenorphine/ or exp naloxone/
 15. exp Methadone/
 16. (suboxone or methadone or buprenorphine or naloxone).ti,ab,kw,kf.
 17. 10 or 11 or 12 or 13 or 14 or 15 or 16
 18. 9 and 17
 19. Limit 18 to humans
Web of Science—All databases:
 1. TS = (genome-wide association study or genome-wide association or GWAS or GWA or genome wide or genome)
 2. TS = ((opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*) NEAR/2 (overdose* or use* or using or misus* or abus* or dependence* or addict*))
 3. TS = ((treatment* or therap*) NEAR/2 (opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*))
 4. TS = (methadone or buprenorphine or naloxone or naltrexone or heroin-assisted or suboxone)
 5. #3 or #4
 6. #1 and #2 and #5
EMBASE (Ovid):
 1. Genome-Wide Association Study/
 2. Genotyping Techniques/
 3. Genome, Human/
 4. Genetic Variation/
 5. genetics/or exp human genetics/
 6. (human* adj2 (genotyp* or genome* or genetic*)).ti,ab,kw.
 7. (GWS or GWAS or GWA).mp.
 8. genome wide.ti,ab,kw.
 9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8
 10. exp Opioid-Related Disorders/
 11. ((opiate* or opioid* or heroin* or codeine* or dilaudid* or fentanyl* or narcotic* or drug* or substance*) adj2 (overdose* or use* or using or misuse* or abus* or dependence* or addict*)).ti,ab,kw.
 12. Opiate Substitution Treatment/
 13. ((opiate* or opioid*) adj2 (treatment* or therap*)).ti,ab,kw.
 14. exp buprenorphine/or exp naloxone/
 15. exp Methadone/
 16. (suboxone or methadone or buprenorphine or naloxone).ti,ab,kw.
 17. 10 or 11 or 12 or 13 or 14 or 15 or 16
 18. 9 and 17
 19. Limit 18 to human
CINAHL and Pre-CINAHL:
 1. genome-wide association study or genome-wide association or GWAS or GWA or genome wide or genome
 2. opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*
 3. overdose* or use* or using or misus* or abus* or dependence* or addict*
 4. S2 and S3
 5. treatment* or therap*
 6. S5 and S2
 7. methadone or buprenorphine or naloxone or naltrexone or heroin-assisted or suboxone
 8. S6 or S7
 9. S1 and S4 and S8
 10. Limit to Human
GWAS Catalog—publications:
 - methadone
 - opioid
 - heroin
 - drug abuse
GWAS Central—studies list:
 - methadone
 - heroin
 - opioid
 - opiate
 - addiction
 - drug abuse
 - opioid dependence
 - opioid addiction
 - fentanyl
NIH Database of Genotypes and Phenotypes:
 - Search (opioid)
 - Search (heroin)