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Table 1 Search strategy

From: GWAS-identified genetic variants associated with medication-assisted treatment outcomes in patients with opioid use disorder: a systematic review and meta-analysis protocol

Medline (Ovid):

 1. Genome-Wide Association Study/

 2. Genotyping Techniques/

 3. Genome, Human/

 4. Genetic Variation/

 5. genetics/or exp human genetics/

 6. (human* adj2 (genotyp* or genome* or genetic*)).ti,ab,kw,kf.

 7. (GWS or GWAS or GWA).mp.

 8. genome wide.ti,ab,kw,kf.

 9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8

 10. exp Opioid-Related Disorders/

 11. ((opiate* or opioid* or heroin* or codeine* or dilaudid* or fentanyl* or narcotic* or drug* or substance*) adj2 (overdose* or use* or using or misuse* or abus* or dependence* or addict*)).ti,ab,kw,kf.

 12. Opiate Substitution Treatment/

 13. ((opiate* or opioid*) adj2 (treatment* or therap*)).ti,ab,kw,kf.

 14. exp buprenorphine/ or exp naloxone/

 15. exp Methadone/

 16. (suboxone or methadone or buprenorphine or naloxone).ti,ab,kw,kf.

 17. 10 or 11 or 12 or 13 or 14 or 15 or 16

 18. 9 and 17

 19. Limit 18 to humans

Web of Science—All databases:

 1. TS = (genome-wide association study or genome-wide association or GWAS or GWA or genome wide or genome)

 2. TS = ((opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*) NEAR/2 (overdose* or use* or using or misus* or abus* or dependence* or addict*))

 3. TS = ((treatment* or therap*) NEAR/2 (opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*))

 4. TS = (methadone or buprenorphine or naloxone or naltrexone or heroin-assisted or suboxone)

 5. #3 or #4

 6. #1 and #2 and #5

EMBASE (Ovid):

 1. Genome-Wide Association Study/

 2. Genotyping Techniques/

 3. Genome, Human/

 4. Genetic Variation/

 5. genetics/or exp human genetics/

 6. (human* adj2 (genotyp* or genome* or genetic*)).ti,ab,kw.

 7. (GWS or GWAS or GWA).mp.

 8. genome wide.ti,ab,kw.

 9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8

 10. exp Opioid-Related Disorders/

 11. ((opiate* or opioid* or heroin* or codeine* or dilaudid* or fentanyl* or narcotic* or drug* or substance*) adj2 (overdose* or use* or using or misuse* or abus* or dependence* or addict*)).ti,ab,kw.

 12. Opiate Substitution Treatment/

 13. ((opiate* or opioid*) adj2 (treatment* or therap*)).ti,ab,kw.

 14. exp buprenorphine/or exp naloxone/

 15. exp Methadone/

 16. (suboxone or methadone or buprenorphine or naloxone).ti,ab,kw.

 17. 10 or 11 or 12 or 13 or 14 or 15 or 16

 18. 9 and 17

 19. Limit 18 to human

CINAHL and Pre-CINAHL:

 1. genome-wide association study or genome-wide association or GWAS or GWA or genome wide or genome

 2. opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*

 3. overdose* or use* or using or misus* or abus* or dependence* or addict*

 4. S2 and S3

 5. treatment* or therap*

 6. S5 and S2

 7. methadone or buprenorphine or naloxone or naltrexone or heroin-assisted or suboxone

 8. S6 or S7

 9. S1 and S4 and S8

 10. Limit to Human

GWAS Catalog—publications:

 - methadone

 - opioid

 - heroin

 - drug abuse

GWAS Central—studies list:

 - methadone

 - heroin

 - opioid

 - opiate

 - addiction

 - drug abuse

 - opioid dependence

 - opioid addiction

 - fentanyl

NIH Database of Genotypes and Phenotypes:

 - Search (opioid)

 - Search (heroin)