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Table 4 Median risk ratio for each treatment compared against placebo in all five network meta-analyses

From: Patient characteristics as effect modifiers for psoriasis biologic treatment response: an assessment using network meta-analysis subgroups

TreatmentMedian risk ratio versus placebo–PASI 75 (95% CrI)
All licensed dosesNo previous biologic use (< 25%)PASI score ≤ 25Weight ≤ 90 kg≥ 90% white patients
Adalimumab 40 mg12.74 (11.00–14.49)12.48 (10.91-14.13)13.09 (11.72-14.57)12.87 (10.29-15.39)13.18 (11.21-15.15)
Brodalumab 210 mg16.76 (15.12–18.53)16.45 (14.66–18.31)16.62 (15.20–18.18)16.73 (14.97–18.58)16.56 (15.02–18.24)
Certolizumab 200 mg12.07 (9.62–14.54)13.93 (8.63–18.20)12.08 (10.30–13.94)11.71 (9.11–14.27)12.13 (10.02–14.26)
Certolizumab 400 mg13.47 (11.09–15.80)15.73 (10.81–19.08)13.42 (11.65–15.23)13.04 (10.53–15.46)13.48 (11.42–15.52)
Etanercept 25 mg7.61 (5.52–10.11)7.64 (6.20–9.20)7.89 (5.60–10.51)
Etanercept 50 mg once–weekly10.67 (7.96–13.53)5.08 (3.50–7.07)6.16 (4.69–7.90)5.57 (3.91–7.65)7.07 (4.57–10.20)
Etanercept 50 mg twice per week9.90 (8.68–11.21)9.46 (8.27–10.77)10.40 (9.47–11.40)9.85 (8.27–11.55)10.33 (9.01–11.75)
Guselkumab 100 mg17.06 (15.30–18.91)16.68 (15.07–18.42)16.83 (15.32–18.46)15.30 (10.89–18.39)
Infliximab 5 mg16.22 (14.37–18.15)16.88 (14.66–19.03)15.46 (13.85–17.17)14.19 (11.76–16.56)15.38 (13.41–17.36)
Ixekizumab 80 mg17.64 (16.06–19.36)17.42 (15.89–19.09)17.79 (16.30–19.41)17.16 (14.67–19.33)17.75 (16.23–19.41)
Risankizumab 150 mg16.46 (14.37–18.47)
Secukinumab 300 mg16.45 (14.79–18.23)16.03 (14.41–17.73)16.43 (15.03–17.96)16.12 (14.55–17.82)18.67 (16.22–20.81)
Ustekinumab 45 mg13.59 (11.79–15.44)12.20 (10.32–14.14)13.46 (12.17–14.84)13.04 (10.35–15.63)13.68 (11.95–15.48)
Ustekinumab 90 mg14.67 (12.85–16.54)13.36 (11.29–15.38)14.51 (13.20–15.95)14.36 (10.18–17.57)14.64 (13.00–16.37)
Ustekinumab (45 mg or 90 mg)12.85 (11.07–14.67)12.96 (11.05–14.94)13.19 (11.79–14.66)13.11 (10.99–15.20)13.14 (11.35–14.95)
Tildrakizumab 100 mg14.86 (12.49–17.02)15.03 (13.18–16.91)15.82 (14.25–17.50)15.28 (13.31–17.21)16.21 (14.20–18.16)
Apremilast5.80 (4.20–7.61)3.77 (2.48–5.59)5.17 (4.01–6.61)3.91 (2.60–5.79)5.46 (4.12–7.10)
Dimethyl Fumarate2.97 (1.44–5.73)2.97 (1.77–4.88)2.97 (1.71–5.01)2.96 (1.71–4.98)
Fumaderm3.31 (1.62–6.26)3.32 (1.97–5.41)3.31 (1.94–5.53)3.30 (1.92–5.48)
Methotrexate6.15 (4.07–8.65)10.47 (6.73–14.41)6.50 (4.69–8.60)5.49 (3.56–8.12)6.30 (4.37–8.61)
Acitretin4.024 (1.55–8.39)4.07 (1.59–8.29)4.29 (1.74–8.43)
Cyclosporin 1.5 mg8.10 (2.41–16.91)2.14 (0.38–10.53)
Cyclosporin 2.5 mg7.10 (2.02–16.34)6.76 (2.07–16.03)