Table 2 PICOS eligibility criteria as adapted for full-text assessment
From: Vitamin B—Can it prevent cognitive decline? A systematic review and meta-analysis
Included in review | Excluded from review | |
|---|---|---|
Patient population | Healthy individuals Pre-existing conditions other than stated on the right | Any form of cognitive impairment Pre-existing mental disorders Children and adolescents Pregnant women |
Intervention | Oral supplementation with vitamin B • B1/B6/folic acid/B12 • Single or in different combinations • Combined with other micro-nutrients | Additional interventions other than stated on the left Use of vitamin B not explicitly stated |
Comparison | Control group (placebo) | Any other |
Outcomes | Global cognition Change in cognitive performance from baseline to the follow-up last available | Non-cognitive outcome measures Studies lacking data on change of cognitive measures |
Study design | RCTs (randomized controlled trials) Controlled studies | Reviews Commentaries Non-controlled studies (pre-post design) |