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Table 1 Characteristics of abstracted studies

From: Increased circulating vascular endothelial growth factor in acute myeloid leukemia patients: a systematic review and meta-analysis

Author, yearRegionPatients with AMLControlSample typeAssay methodStudy typeCriteria for the classification of AMLNOS
NAge, mean ± sd, years% femaleVEGF mean ± sd, pg/mlNAge, mean ± sd, years% femaleVEGF, mean ± sd, pg/ml
Aguayo et al., 2000 [16]American115NANA30.43 ± 69.6311NANA32.63 ± 9.50PlasmaELISACase-controlNA6
Aguayo et al., 2002 [27]American58NANA30.63 ± 92.094339.00 ± 13.75NA27.30 ± 17.08PlasmaELISACase-controlFAB7
Aref et al., 2002 [25]Egypt6347.00 ± 12.5028/6378.00 ± 47.25a15NANA33.03 ± 13.76aPlasmaELISACase-controlFAB7
Wang et al., 2003 [28]China3942.00 ± 14.7519/39135.30 ± 87.9012NANA80.60 ± 33.10PlasmaELISACase-controlNA6
Xie and Qi, 2003 [24]China25NANA201.43 ± 51.843036.71 ± 11.7514/30100.53 ± 47.67SerumELISACase-controlFAB6
Wierzbowska et al., 2003 [30]Poland38NANA32.60 ± 651.2012NANA44.40 ± 31.60PlasmaELISACase-controlFAB6
Wang et al., 2004 [29]China10742.00 ± 11.8359/107154.75 ± 109.9826NANA99.91 ± 41.87PlasmaELISACase-controlFAB6
Kim et al., 2005 [17]Korea2841.50 ± 14.75bNA54.30 ± 113.1517NANA238.95 ± 136.25SerumELISACase-controlNA6
Aref et al., 2005 [26]Egypt43NANA373.90 ± 222.9510NANA138.00 ± 14.86PlasmaELISACase-controlFAB6
Erdem et al., 2006 [23]Turkey1532.60 ± 18.805/15110.10 ± 120.902034.00 ± 11.908/2069.90 ± 24.40SerumELISACase-controlNA7
Zhao and Zhao, 2007 [22]China15NANA377.49 ± 146.3115NANA77.11 ± 21.37SerumELISACase-controlNA6
Dincaslan et al., 2010 [31]Turkey77.17 ± 4.844/7286.50 ± 328.8120NANA190.50 ± 117.50SerumELISACase-controlFAB7
Song et al., 2015 [21]China28NANA74.97 ± 29.0410NANA41.76 ± 10.03SerumELISACase-controlFAB/WHO7
Yang et al., 2016 [20]China6851.00 ± 12.3732/68293.21 ± 57.542049.00 ± 8.9410/20133.00 ± 24.65PlasmaELISACase-controlFAB/WHO7
  1. N number, NA not available, VEGF vascular endothelial growth factor, AML acute myeloid leukemia, ELISA enzyme-linked immunosorbent assay, NOS Newcastle-Ottawa Scale
  2. aNanograms per milliliter
  3. bOf 30 people’s age (mean ± sd)