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Table 2 Data collection items

From: Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus

DomainData items
Study characteristicsStudy ID, year of publication, the country where the study conducted, sponsorship (funding source)
Study populationAnimal species, strain, age, gender, weight, and co-morbidities
T2DM modelsChemical, genetic, surgical, high-fat diet
Intervention and comparisonTaxonomical assessment (scientific name, family, identification of specimen, voucher specimen number), source, part used, description of the preparation, quality control measures, dosage, time of administration, route of administration, and duration of administration
Outcome measuresFPG, HbA1c, IGT, HOMA-IR, HOMA-B, serum insulin concentration, whole pancreas insulin content, morphometrics of pancreases, FFAs, TGs, TC, HDL cholesterol, LDL cholesterol, liver glycogen, ALT, AST, ALP, GGT, urea, BUN, serum creatinine, total protein, albumin, globulin, bilirubin total, calcium, phosphorus, death, Hb, packed cell volume, total red blood cells, total white blood cells, differential white cell counts, platelet count, and absolute red blood cell indices.
Risk of bias assessment and quality of reporting of preclinical studyBaseline data (weight, microbiological status, age, drug- or test-naïve), Sequence generation, allocation concealment, random housing, blinding of investigators/caregivers, random outcome assessment, blinding of the assessor, incomplete outcome data, selective outcome reporting and other source of bias, blinded assessment of outcome, publication after peer review, statement of temperature control, appropriate animal model (aged, diabetic mellitus, type 2), sample size calculation, compliance with animal welfare regulations, statement of potential conflict of interests
  1. GGT gamma-glutamyl transpeptidase, FPG fasting plasma glucose, non-FPG non-fasting plasma glucose, HbA1c glycosylated hemoglobin A1c, IGT impaired glucose tolerance, HOMA-IR homeostatic model assessment of insulin resistance, HOMA-B homeostatic model assessment of β cell function, FFAs free fat acids, TGs triglycerides, TC total cholesterol, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphase, BUN blood urea nitrogen