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Table 1 Common animal models of type 2 diabetes mellitus

From: Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus

Induction mechanism

Model (species/strains)

Chemically

 

 i. Streptozotocin

n-STZ, NAD-STZ, STZ-S

 ii. Alloxan

Rats, mice, non-primates

 iii. Goldthioglucose

Obese diabetic mouse

Genetically

 

 i. Obese (monogenic)

Lepob/ob mice, Leprdb/db mice, Zucker diabetic fatty rats

 ii. Obese (polygenic)

KK mice, NZO mice, TallyHo/Jng mice NoncNZO10/LtJ mice, TSOD, OLETF rat

 iii. Beta cell dysfunction

hIAPP mice, AKITA mice

 iv. Spontaneously

Obese rhesus monkey (Macaca mullata)

 v. Non-obese (polygenic)

Goto–Kakizaki rats

Obese

 

 High-fat feeding

C57BL/6J mice, Desert gerbil (Psammomys obesus), Nile grass rat (Arvicanthis niloticus), Wistar Albino rats

Surgically

 

 Partial pancreatectomy in animals

Rabbits, diabetic dog model

  1. OLETF Otsuka Long-Evans Tokushima Fat rat, NZO New Zealand Obese mice, n-STZ neonatal streptozotocin-induced diabetes rat, NAD-STZ nicotinamide-streptozotocin-induced diabetic, STZ-S sucrose-challenged streptozotocin-induced diabetes rat, KK Kuo Kundo, TSOD Tsumara Suzuki Obese Diabetes mice