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Table 1 Common animal models of type 2 diabetes mellitus

From: Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus

Induction mechanismModel (species/strains)
 i. Streptozotocinn-STZ, NAD-STZ, STZ-S
 ii. AlloxanRats, mice, non-primates
 iii. GoldthioglucoseObese diabetic mouse
 i. Obese (monogenic)Lepob/ob mice, Leprdb/db mice, Zucker diabetic fatty rats
 ii. Obese (polygenic)KK mice, NZO mice, TallyHo/Jng mice NoncNZO10/LtJ mice, TSOD, OLETF rat
 iii. Beta cell dysfunctionhIAPP mice, AKITA mice
 iv. SpontaneouslyObese rhesus monkey (Macaca mullata)
 v. Non-obese (polygenic)Goto–Kakizaki rats
 High-fat feedingC57BL/6J mice, Desert gerbil (Psammomys obesus), Nile grass rat (Arvicanthis niloticus), Wistar Albino rats
 Partial pancreatectomy in animalsRabbits, diabetic dog model
  1. OLETF Otsuka Long-Evans Tokushima Fat rat, NZO New Zealand Obese mice, n-STZ neonatal streptozotocin-induced diabetes rat, NAD-STZ nicotinamide-streptozotocin-induced diabetic, STZ-S sucrose-challenged streptozotocin-induced diabetes rat, KK Kuo Kundo, TSOD Tsumara Suzuki Obese Diabetes mice