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Table 1 Summary of moderators

From: Sexual dysfunction and satisfaction in obsessive compulsive disorder: protocol for a systematic review and meta-analysis

ModeratorHypothesisRationale and evidence for moderators
AgeYounger age is hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher sexual satisfactionSystematic review and community studies showed that younger age is associated with lower prevalence of sexual dysfunction [48,49,50]
GenderMale gender is hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher levels of sexual satisfactionObservational studies in clinical samples with OCD showed that females had higher prevalence of sexual dysfunctions than men [34]
Married/Cohabitant statusMarried/cohabitant status is hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher sexual satisfactionMarried/cohabitant status was found to be associated with lower prevalence of sexual dysfunctions [50]
OCD symptom severityHigher OCD severity is hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher sexual satisfactionSystematic review showed that higher OCD was associated with worse outcomes in a variety of quality of life domains [5]
Comorbid depressive disordersLower percentage of comorbid depressive disorders are hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher sexual satisfactionObservational studies in clinical and non-clinical samples showed that comorbid depressive disorders and/or or symptoms [34, 52]
Comorbid anxiety disordersLower percentage of comorbid anxiety disorders are hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher sexual satisfactionObservational studies showed that anxiety disorders are associated with sexual dysfunctions and/or lower sexual satisfaction [53, 54]
Concurrent psychiatric medicationLack of concurrent psychiatric medication is hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher sexual satisfactionLongitudinal and cross-sectional studies showed that psychiatric medication, specifically antidepressants, are associated with higher levels and prevalence of sexual dysfunctions [36,37,38]
Comorbid medical diseaseComorbid medical disease is hypothesized to be associated with lower levels of and lower risk for sexual dysfunction, higher sexual satisfactionSystematic reviews showed that general medical disease is associated with a higher prevalence of sexual dysfunctions [54,55,56]