| Descriptive characteristics of the study | • Location of the study |
| • Study design |
| Type of sample, source and outcome | • Environmental media or biological sample type tested |
| • Location of the WWTP where the sample(s) was (were) taken |
| • Quantity of samples |
| • Bacterial species and/or genes analyzed |
| • Microbiological method used |
| Type of exposure | • Categorical: Downstream, downwind or down-gradient |
| • Continuous: Distance to the WWTP; distance to the Comparator |
| Type of comparator | • Categorical: Upstream, upwind or up-gradient |
| • Continuous: Distance to the WWTP; distance to the exposure site? |
| Sample size | • If exposure is categorical: Sample size of each group |
| • If exposure is continuous: Total sample size |
| If statistical modelling was used | • Type of model |
| • Effect measure (extracted or computed if there is enough raw data reported) |
| • Measure of variability |
| • p value |
| Confounding control | • Methods to account for confounding or account for clustering data |
| Measure of resistance | • Proportional: Is denominator present? Was the denominator stable across sampling sites? |
| • Absolute |
