A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome

Table 3 Summary of genotyping secondary outcomes

Author	Year	Assessed	Method	Significance	NS
Brenu et al. [2]	2011	NK cell lytic proteins	qRT-PCR	Granzyme A (p < 0.05) Graznyme K (p < 0.05) IFN-γ (p < 0.05)
Marshall-Gradisnik et al. [44]	2016	NK cell ion channel SNP		TRPC4 (p < 0.05) TRPC2 (p < 0.05) TRPM3 (p < 0.05) TRPM8 (p < 0.05)
Marshall-Gradisnik et al. [44]	2016	AChR receptors		CHRNA3 (p < 0.05) CHRNA2 (p < 0.05) CHRNB4 (p < 0.05) CHRNA5 (p < 0.05) CHRNE (p < 0.05)
Theorell et al. [47]	2017	Perforin (PRF1)	PCR		PRF1

NK natural killer, NS no significance, qRT-PCR qualitative reverse transcription polymerase change reaction, SNP single-nucleotide polymorphism, PCR polymerase chain reaction, AChR acetylcholine receptors, TRPC transient receptor potential canonical, TRPM transient receptor potential melastatin

ISSN: 2046-4053