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Table 1 Summary of study and participant characteristics

From: A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome

Paper detailsSample size
AuthorYearStudy designDiagnostic criteriaCountrySampleME/CFS (female%)[years]HC (female%)[years]
Brenu et al. [42]2010Case ControlFukudaAustraliaNK cells1010
Brenu et al. [2]2011Case ControlFukudaAustraliaNK cells95 (70.5%) [46.47 ± 11.7]50 (57.7%) [41.9 ± 9.6]
Brenu et al. [43]2012Case ControlFukudaAustraliaNK cells65 (75.4%) [47.2 ± 11.5]21 (66.7%) [45.2 ± 9.3]
Brenu et al. [14]2013Case ControlFukudaAustraliaPBMCs30 [51.15 ± 1.92]25 [50.42 ± 1.76]
Curriu et al. [48]2013Case ControlFukudaSpainPBMCs22 (73%) [44]30 (55%) [38]
Fletcher et al. [45]2010Case ControlFukudaUSAPBMCs176 (83%) [44]230 (86%) [41]
Hardcastle et al. [46]2015Case ControlFukudaAustraliaPBMCsSevere n = 12 (83%) [41.27 ± 10.05]18 (72%)[41.94 ± 10.76]
Moderate n = 12 (67%) [44.73 ± 12.9]
Hardcastle et al. [46]2015Case ControlFukudaAustraliaPBMCs, NK cellsSevere n = 12 (83.3%) [41.25 ± 2.77]18 (66.7%) [40.39 ± 2.65]
Moderate n = 15 (73.3%) [45.93 ± 2.96]
Huth et al. [21]2014Case ControlFukudaAustraliaNK cells29 [48.28 + 2.63]27 [49.15 + 2.51]
Huth et al. [16]2016Case ControlFukudaAustraliaPBMCs14 [53.5 ± 2.17]11 [48.82 ± 3.46]
Maher et al. [20]2005Case ControlFukudaUSAWhole blood30 (83.3%) [46 ± 10]19 [43 ± 10]
Marshall-Gradisnik et al. [44]2016Case ControlFukudaAustraliaNK cells39 (71.8%) [51.69 ± 2]30 (56.7%) [47.6 ± 2.39]
Nguyen et al. [49]2016Case ControlFukudaAustraliaPBMCs17 (82%) [48.68 ± 1.06]19 (68%) [46.48 ± 1.22]
Nguyen et al. [5]2017Case ControlFukudaAustraliaNK cells25 (68%) [48.82 ± 9.84]15 (70.6%) [39.2 ± 12.12]
Rivas et al. [51]2018Case ControlCCCSpainWhole blood76 (82.9%) [49.78]73 (82.2%) [48.71]
Stewart et al. [50]2003Case ControlFukudaUSAWhole blood90 (69%) [36.7 ± 7.3]50 (76%) [35.7 ± 9.2]
Theorell et al. [47]2017Case ControlCCCSweden, NorwayPBMCs24 (75%) [44]a28 (71%) [44]a
24 (79%) [30]b24 (79%) [30]b
  1. ME/CFS myalgic encephalomyelitis/chronic fatigue syndrome, HC healthy control, USA United States of America, NK natural killer, PBMC peripheral blood mononuclear cells
  2. aLocation: Stockholm
  3. bLocation: Oslo