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Table 2 Results of AMSTAR-2

From: An overview of systematic reviews of complementary and alternative therapies for infantile colic

Author (date) CAM1. Were PICO components listed?2. Protocol reported? Any deviations justified?3. Study design justified?4. Comprehensive literature search?5. Was study selection performed in duplicate?6. Was data extraction performed in duplicate?7. List of excluded studies? Were these justified?8. Characteristics of studies provided in detail?9. Risk of bias assessed?10. Sources of funding of included studies?11. Methods used to combine the findings of studies appropriate? Test on heterogeneity?12. If meta-analysis performed was RoB accounted for?13. Was RoB discussed in individual studies?14. Was there discussion of any heterogeneity observed in the results?15. If a quantitative synthesis, was publication bias investigated and discussed in relation to the results?16. Reviewers’conflict of interests stated?Confidence in the review
Multiple CAM therapies 
 Perry [22]YesPYNoPYPYYesNoYesYesNoNo MANo MAYesNoNo MAYesLow
 Bruyas-Bertholon [23]NoNoNoNoNoNoNoPYPYNoNo MANo MANoNoNo MANoCL
 Harb [24]YesNoNoNoYesYesNoPYYesNoYesYesYesNoYesYesCL
 Gutierrez-Castrellon [25]YesNoNoNoNoNoNoNoNoNoNoNoYesNoYesNoCL
Manipulation therapies
 Dobson [26]YesYesNoYesYesYesYesYesYesNoYesYesYesNoaYesYesHigh
 Gleberzon [27]NoNoNoPYNoYesNoPYNoNoNo MANo MAYesNoNo MANoCL
 Carnes [28]NoPYNoPYYesYesNoPYYesNoNoNoNoNoNoNoCL
Acupuncture 
 Skejeie [29]YesPYNoYesYesYesNoYesYesNoYesYesYesYesNoNodLow
Herbal medicines 
 Anheyer [30]NoNoNoNoNoYesNoYesYesNoNo MANo MANoNoNo MAYesCL
Probiotics 
 Sung [31]YesNoNoNoYesYesYesPYYesNoYesNoYesNoNoYesCL
 Anabrees [32]YesPYNoPYNoYesNoYesYesNoYesNoYesYesNoYesLow
 Urbanska [33]YesNoNoPYNoNoNoPYYesYesNoNoNoNoNoNoCL
 Xu [34]NoNoNoPYYesYesNoYesYesNoYesNoNoNoNoYesCL
 Schreck Bird [35]YesNoNoNoYesNoNoYesYesNoNoNoNoNoNoNoCL
 Dryl [36]YesNoNoNoNoNoNoPYYesNoNoNoNoNoNoNoCL
 Sung [37]YesPYNoPYbNoNoNoNoYesNoYesYesYesYesYesNocLow
  1. CL critically low, PY partial yes, MA meta-analysis, PICO participants, intervention, comparator, outcomes, RoB risk of bias
  2. Grey columns represent the critical domains (see Additional file 1)
  3. aToo few studies to perform a test of heterogeneity
  4. bNot fully searched and search conducted Dec 2014
  5. cConflict of interest occurred but no indication of how it was dealt with
  6. dAll included studies were by the author team but did not indicate how this was dealt with