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Table 3 Summary of differences between groups at final follow-up on measures of cognitive function

From: Screening for thyroid dysfunction and treatment of screen-detected thyroid dysfunction in asymptomatic, community-dwelling adults: a systematic review

Test

Author (total sample size; treatment vs. control)

Difference*

95% CI

California Computerized Assessment Package

Jorde et al. [63] (68; 35 vs. 33)

− 79.00

− 229.88 to 71.88

Composite cognitive score

Jorde et al. [63] (65; 35 vs. 30)

2.40

0.29–4.51

Controlled Word Association test

Jorde et al. [63] (69; 36 vs. 33)

0.10

− 6.77 to 6.97

Letter Digit Coding test

Stott et al. [73] (600; 302 vs. 298)

− 0.1

− 0.9 to 0.7

Middlesex Elderly Assessment of Mental State

Parle et al. [71] (82; 46 vs. 36)

0.34

− 0.08 to 0.76

Mini-Mental State Examination

Parle et al. [71] (82; 46 vs. 36)

0.03

− 0.89 to 0.95

Seashore Rhythm test

Jorde et al. [63] (68; 35 vs. 33)

− 37.00

− 89.85 to 15.85

Speed and Capacity of Language Processing test

Parle et al. [71] (85; 49 vs. 36)

1.47

0.05–2.89

Trail Making Test A

Jorde et al. [63] (69; 36 vs. 33)

− 5.10

− 12.84 to 2.64

Parle et al. [71] (84; 48 vs. 36)

− 2.45

− 11.1 to 6.2

Trail Making Test B

Jorde et al. [63] (66; 36 vs. 30)

− 9.00

− 35.79 to 17.79

Parle et al. [71] (82; 48 vs. 34)

− 11.71

− 45.20 to 21.78

Trail Making Test B-A

Parle et al. [71] (82; 48 vs. 34)

−11.61

−37.91 to 14.69

Vocabulary – Wechsler Intelligence Scale

Jorde et al. [63] (69; 36 vs. 33)

0.10

− 1.73 to 1.93

Word List test

Jorde et al. [63] (68; 35 vs. 33)

1.10

− 2.63 to 4.83

  1. *Value is the difference in mean scores at final follow-up between treatment and control groups