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Table 3 Summary of differences between groups at final follow-up on measures of cognitive function

From: Screening for thyroid dysfunction and treatment of screen-detected thyroid dysfunction in asymptomatic, community-dwelling adults: a systematic review

Test Author (total sample size; treatment vs. control) Difference* 95% CI
California Computerized Assessment Package Jorde et al. [63] (68; 35 vs. 33) − 79.00 − 229.88 to 71.88
Composite cognitive score Jorde et al. [63] (65; 35 vs. 30) 2.40 0.29–4.51
Controlled Word Association test Jorde et al. [63] (69; 36 vs. 33) 0.10 − 6.77 to 6.97
Letter Digit Coding test Stott et al. [73] (600; 302 vs. 298) − 0.1 − 0.9 to 0.7
Middlesex Elderly Assessment of Mental State Parle et al. [71] (82; 46 vs. 36) 0.34 − 0.08 to 0.76
Mini-Mental State Examination Parle et al. [71] (82; 46 vs. 36) 0.03 − 0.89 to 0.95
Seashore Rhythm test Jorde et al. [63] (68; 35 vs. 33) − 37.00 − 89.85 to 15.85
Speed and Capacity of Language Processing test Parle et al. [71] (85; 49 vs. 36) 1.47 0.05–2.89
Trail Making Test A Jorde et al. [63] (69; 36 vs. 33) − 5.10 − 12.84 to 2.64
Parle et al. [71] (84; 48 vs. 36) − 2.45 − 11.1 to 6.2
Trail Making Test B Jorde et al. [63] (66; 36 vs. 30) − 9.00 − 35.79 to 17.79
Parle et al. [71] (82; 48 vs. 34) − 11.71 − 45.20 to 21.78
Trail Making Test B-A Parle et al. [71] (82; 48 vs. 34) −11.61 −37.91 to 14.69
Vocabulary – Wechsler Intelligence Scale Jorde et al. [63] (69; 36 vs. 33) 0.10 − 1.73 to 1.93
Word List test Jorde et al. [63] (68; 35 vs. 33) 1.10 − 2.63 to 4.83
  1. *Value is the difference in mean scores at final follow-up between treatment and control groups