|Stage||Elements of the review process|
|Stage 1: initial systematic mapping review of prognostic research||
A descriptive map of prognostic research for lung cancer survival based on the assessment of titles and abstracts only.|
● Classification of relevant reviews and meta-analysis according to PROGRESS research themes 1–4, lung cancer type, number and type of prognostic factors investigated, and publication type.
● Identification of all prognostic factors, from which a comprehensive coding scheme was developed.
● Identification of prognostic factors deemed to be potentially modifiable (reviewed by two independent public health and clinical stakeholders).
|Stage 2: overview of systematic reviews of prognostic factor research||
A more in-depth review of a subset of systematic reviews focusing on prognostic factor research (PROGRESS research theme 2) based on the assessment of full text publications.|
● Summary of key data from included reviews.
● Coding of reviews according to the prognostic factors they addressed.
● Summary of all prognostic factors investigated by each review, including whether or not they were significantly associated with survival†, and the direction of the impact.
|Stage 3: in-depth evaluation of potentially modifiable factors||
A more in-depth evaluation of the results of included reviews reporting modifiable factors.|
● Summary of the magnitude of the effect of modifiable prognostic factors (where possible).